filaggrin dries out and weakens that skin barrier. People who don't make enough of these proteins lose more water from their skin, which causes the dryness and itchiness of eczema. This makes skin vulnerable to irritants, like soaps and detergents. It also makes it easier for allergens to ...
The FLG gene provides instruction to make the protein called filaggrin, which is required for creating a strong outermost layer of the skin since it acts as a barrier and a natural moisturizer at the same time. The mutation of the FLG gene leads to a shortage of such protein, thereby makin...
McAleer MA, Irvine AD (2013) The multifunctional role of filaggrin in allergic skin disease. J Allergy Clin Immunol 131:280–291 CAS PubMed Google Scholar Millioni R, Puricelli L, Iori E, Trevisan R, Tessari P (2012) Skin fibroblasts as a tool for identifying the risk of nephropathy ...
(2023) provided evidence that malignant T cells in CTCL secrete cytokines IL-13, IL-22, and oncostatin M (OSM) to induce JAK-STAT signaling in the surrounding keratinocytes; downregulate the filaggrin expression; and impair the skin barrier function [10]. This toxic effect on the skin is ...