Alternative SplicingProtein-Tyrosine KinasesMolecular Sequence DataEmbryo, MammalianThe gene for fibroblast growth factor receptor-2 (FGFR2) encodes two splice variants designated here as keratinocyte growth factor (KGFR) and bek. Their ligand-binding specificity is markedly different due to mutually ...
Current progress in cancer treatment by targeting FGFR signaling, Cancer Biology & Medicine, 2023 Alternative Splicing of Fibroblast Growth Factor Receptor IgIII Loops in Cancer, Journal of Nucleic Acids, 2012 Clinicogenomic Analysis of FGFR2-Rearranged Cholangiocarcinoma Identifies Correlates of Response a...
1.Splice variants: Alternative splicing may create different sized proteins from the same gene. 2. Relative charge: The composition of amino acids may affects the charge of the protein. 3. Post-translational modification: Phosphorylation, glycosylation, methylation etc. ...
Amp, gene amplification. FGFR2-int- 14 and FGFR2-int-12, different primers for intron 14 or intron 12 of FGFR2. & 2012 Cancer Research UK British Journal of Cancer (2012) 106(4), 727 – 732 FGFR2 amplification in gastric cancer K Matsumoto et al 730 cases (92.0, 63.0, 41.4, ...
1.Splice variants: Alternative splicing may create different sized proteins from the same gene. 2. Relative charge: The composition of amino acids may affects the charge of the protein. 3. Post-translational modification: Phosphorylation, glycosylation, methylation etc. 4. Post-translation cleavage: ...
Missense mutations in the Fibroblast Growth Factor Receptor 2 (FGFR2) have been identified in human craniosynostotic syndromes such as Crouzon (CS) and Pfeiffer (PS). FGFR2 has two major isoforms, IIIb and IIIc, generated through alternative splicing with their own temporal, spatial, and ...
Alternative splicing generates multiple forms of FGFR1-3, each with unique signaling characteristics (1-3). For FGFR2, alternative splicing of the ECD, specifically the IgIII domain, results in IIIb, or IIIc isoforms (4). The FGFR splice variants also exhibit distinct and varying binding ...
of Nrf-2, alternative splicing of Nrf-2 coding gene or partial cleavage of the protein [48,49,50]. To confirm the specificity of the anti-Nrf-2 antibody, MCF7 and T47D cells were treated with tBHQ (tert-butylhydroquinone)—Nrf-2 inductor, which was previously shown to induce Nrf-2 pr...
K-SAM/FGFR2 gene encodes a receptor tyrosine kinase which belongs to the fibroblast growth factor receptor family and is amplified and overexpressed in KATO-III gastric cancer cells. To characterize K-sam proteins in cancer cells, anti-K-sam rabbit polyclonal antibody PK1-2 was raised and used...
The detection results confirmed that p.Cys342Arg was the hotspot mutation in FGFR2 gene, which accounted for Crouzon syndrome. 【Key words】 Crouzon syndrome;Fibroblast growth factor receptor 2;Gene mutation Crouzon綜合征(MIM 123500)是一种罕见的先天性遗传病,是由于颅骨冠状缝过早骨化闭合而引起的颅...