除佝偻病和骨软化症之外,XLH患者还有沉重的疾病负担,包括关节病、骨关节炎、假性骨折和牙科并发症,所有这些都会降低生活质量。本共识声明介绍欧洲骨质疏松症、骨关节炎和肌肉骨骼疾病临床和经济方面学会(the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases)...
FGF 23 can exert several endocrine functions, such as inhibiting renal phosphate reabsorption and 1,25‐dihydroxyvitamin D3 production. Moreover, it has paracrine activities on several cell types, including neutrophils and hepatocytes. Klotho and Fgf23 deficiencies result in pathologies otherwise ...
除佝偻病和骨软化症之外,XLH患者还有沉重的疾病负担,包括关节病、骨关节炎、假性骨折和牙科并发症,所有这些都会降低生活质量。本共识声明介绍欧洲骨质疏松症、骨关节炎和肌肉骨骼疾病临床和经济方面学会(the European Society for Clinical ...
One of the most important breakthroughs is the identification of fibroblastic growth factor 23 (FGF23) and its role as a key regulator of phosphate and 1,25-dihydroxyvitamin D metabolism. FGF23 exerts its biological functions by binding to its cognate receptor in the presence of Klotho as a ...
These high FGF23 levels have been claimed to be involved not only in the mineral metabolism derangements but also to possibly affect the progression of cardiovascular disease (CVD) and CKD itself, adding negative effects to the poor clinical outcomes of CKD [6-8]....
Imel, E. A. & Econs, M. J. Fibroblast growth factor 23: roles in health and disease.J. Am. Soc. Nephrol.16, 2565–2575 (2005). ArticleCASPubMedGoogle Scholar Quarles, L. D. Endocrine functions of bone in mineral metabolism regulation.J. Clin. Invest.118, 3820–3828 (2008). ...
糖尿病肾脏病(diabetic kidney disease,DKD)是糖尿病(diabetes mellitus,DM)常见的并发症之一,约20%-40%DM患者在发病后的20-25年内进展为DKD,目前在中国DKD已成为住院慢性肾脏病(chronic kidney disease,CKD)的首要病因.骨代谢异常主要表现为骨痛,骨质疏松,骨折或骨骼畸形等骨骼质量和强度的损害,是DKD常见的并发症...
Calcium and phosphorous are coordinately regulated to maintain circulating levels necessary for normal biological functions. Complex hormonal pathways control the levels of calcium and phosphate and prevent adverse consequences of calciu... V David,LD Quarles - 《Vitamin D》 被引量: 1发表: 2011年 Met...
顶/踩数: 0/0 收藏人数: 0 评论次数: 0 文档热度: 文档分类: 论文--毕业论文 系统标签: fgfrs细胞分化klothohspgshbgm 硕士学位论文FGF23/FGFRs调节成骨细胞分化的作用和机制研究莫奇非指导教师陈林教授导师组成员苏楠副教授培养单位陆军军医大学陆军特色医学中心战伤组织修复与康复医学研究室申请学位类别硕士学术学...
Ca, calcium; CKD, chronic kidney disease; FGF23, fibroblast growth factor 23; GBM, glomerular basement membrane; PTH, parathyroid hormone. DISCUSSION We demonstrated that the inhibition of FGF23 activity in rats with mild CKD resulted in high serum phosphate and normal 1,25(OH)2D levels. ...