The discovery of fibroblast growth factor-23 (FGF-23) as a key regulator of phosphate and vitamin D metabolism has forced a rethink about the mineral and bone disorder of chronic kidney disease (CKD). FGF-23 powerfully predicts adverse cardiovascular outcomes in patients with CKD and an ...
There was a significant negative association between serum 25(OH)D levels and iPTH [ r =0.290 ( p <0.0001)]. There was no significant association between serum 25(OH)D levels and FGF23.We show that 28% of Japanese 12- to 13-year-old early adolescents suffer from vitamin D deficiency....
Hyperphosphatemia, vitamin D deficiency, hyperparathyroidism, and high serum fibroblast growth factor 23 (FGF23) levels, when studied separately, were found to predict the progression of CKD. However, studies with simultaneous measurement of mineral bone disorder (MBD)-related factors were scarce. Thi...
early-stage CKD FGF23 phosphate vitamin D Abnormal regulation of mineral ion homeostasis is one of the major problems in patients with chronic kidney disease (CKD). A decrease in the number of functional nephrons has long been thought to lead to impaired urinary phosphate excretion and hyperphosp...
Dietary factors and fibroblast growth factor-23 levels in young adults with African ancestry Article 09 December 2016 Effects of vitamin D supplementation on FGF23: a randomized-controlled trial Article Open access 30 March 2018 Controlled dietary phosphate loading in healthy young men elevates ...
Fibroblast growth factor 23 (FGF23), a hormone primarily produced in bone cells, targets the kidney to accelerate phosphate excretion into the urine and suppresses vitamin D synthesis, thereby inducing a negative phosphate balance. Excessive serum FGF23 due to hereditary disorders such as hypophosphat...
Introduction:The level of fibroblast growth factor 23 (FGF23) may be considered as a prognostic factor for assessing renal function in regulating components of phosphate and vitamin D hemostasis. Objectives:The present study aimed to evaluate the prognostic value of FGF23 level to predict renal func...
To test whether the AKI-induced increase in FGF23 is 1,25D-dependent, we measured 1,25D levels in mice with and without AKI, and repeated the FA experiments in vitamin D receptor (VDR)-null mice. There was no difference in mean plasma 1,25D levels between AKI and control animals 24...
As a pleiotropic multiple functional hormone, FGF23 is involved in the phosphate reabsorption, the regulation of vitamin D production, and the conserving of calcium and sodium level in the kidney (31, 32, 33, 34). There are four receptors of FGFs available (35, 36, 37). At physiological ...
Summary:Recent work regarding FGF23 synthesis and bioactivity, as well as considerations for diseases of altered phosphate balance will be reviewed. 展开 关键词:FAM20C FGF23 Fibroblast growth factor-23 Furin GALNT3 Klotho PSC3 PTH osteomalacia phosphate rickets vitamin D ...