Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of cells. ...
1. Ornitz DM, Itoh N. The Fibroblast Growth Factor signaling pathway. Wiley Interdiscip Rev Dev Biol. 2015 May-Jun;4(3):215-66. 2. Xie Y, Su N, Yang J, Tan Q, et al. FGF/FGFR signaling in health and disease. Signal T...
TGF-β signaling in health, disease and therapeutics Article Open access 22 March 2024 Covert actions of growth hormone: fibrosis, cardiovascular diseases and cancer Article 24 June 2022 References Itoh, N. & Ornitz, D. M. Evolution of the Fgf and Fgfr gene families. Trends Genet. 20,...
Circulating FGF21 levels in human health and metabolic disease. Exp. Clin. Endocrinol. Diabetes. https://doi.org/10.1055/a-0879-2968 (2019). Article PubMed Google Scholar Coskun, T. et al. Fibroblast growth factor 21 corrects obesity in mice. Endocrinology 149, 6018–6027 (2008). CAS ...
In this survey-based study, we examine the nature of hepatic FGF21 activation in liver tissues and tissue sections from several mouse liver disease models and human patients, by quantitative PCR, immunohistochemistry, protein chemistry, and reporter and CHIP assays. The liver diseases include genetic...
内八字步态(In-toeing gait) 关节活动范围缩小 肌无力 牙齿并发症 牙齿坏死伴严重脓肿 颌面部蜂窝组织炎 早期牙齿缺失 评估低磷血症患者 评估疑似低磷酸盐血症患者时,需要考虑磷酸盐值的年龄调整参考值。此外,血清磷酸盐水平表现出昼夜节律,峰值在凌晨3点左右,最低点在上午11点左右22。在某些罕见情况下,由于单克隆...
Guelpa G. Starvation and purgation in the relief of disease. BMJ. 1910;2(2597):1050-1. Reitman ML. FGF21: a missing link in the biology of fasting. Cell Metab. 2007;5(6):405-7. Salminen A, Kaarniranta K, Kauppinen A. Integrated stress response stimulates FGF21 expression: Systemic...
Cardiovascular and metabolic disease (CVMD) is becoming increasingly prevalent in developed and developing countries with high morbidity and mortality. In recent years, fibroblast growth factor 21 (FGF21) has attracted intensive research interest due to its purported role as a potential biomarker and ...
内八字步态(In-toeing gait) 关节活动范围缩小 肌无力 牙齿并发症 牙齿坏死伴严重脓肿 颌面部蜂窝组织炎 早期牙齿缺失 评估低磷血症患者 评估疑似低磷酸盐血症患者时,需要考虑磷酸盐值的年龄调整参考值。此外,血清磷酸盐水平表现出昼夜...
1.本技术是申请日为2015年10月23日的第201580070276.x号发明名称为“修饰的fgf-21多肽及其用途”的中国专利申请的分案申请。 发明领域 2.本发明涉及含有内部缺失的任选地经肽置换的修饰的fgf-21多肽及其用于治疗或预防疾病和病症的用途。 3.发明背景 4.成纤维细胞生长因子是广泛表达于发育和成熟组织中的多肽(baird...