roles in organ development,injury repair,and the pathophysiology of spectrum of diseases,which is a consequence of FGF signaling dysregulation,including cancers and chronic kidney disease(CKD).In this context,the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems...
Fibroblast growth factor 23 (FGF23) is mainly produced in the bone and, upon secretion, forms a complex with an FGF receptor and co‐receptor αKlotho. FGF23 can exert several endocrine functions, such as inhibit renal phosphate reabsorption and 1,25ヾihydroxyvitamin D3 production. Moreover, ...
TGF-β signaling in health, disease and therapeutics Article Open access 22 March 2024 Introduction of the FGF/FGFR signaling Fibroblast growth factors (FGFs) are broad-spectrum mitogens and regulate a wide range of cellular functions, including migration, proliferation, differentiation, and survival...
1. Ornitz DM, Itoh N. The Fibroblast Growth Factor signaling pathway. Wiley Interdiscip Rev Dev Biol. 2015 May-Jun;4(3):215-66. 2. Xie Y, Su N, Yang J, Tan Q, et al. FGF/FGFR signaling in health and disease. Signal T...
内八字步态(In-toeing gait) 关节活动范围缩小 肌无力 牙齿并发症 牙齿坏死伴严重脓肿 颌面部蜂窝组织炎 早期牙齿缺失 评估低磷血症患者 评估疑似低磷酸盐血症患者时,需要考虑磷酸盐值的年龄调整参考值。此外,血清磷酸盐水平表现出昼夜...
Xie, Y. et al. FGF/FGFR signaling in health and disease.Signal. Transduct. Target. Ther.5, 181 (2020). ArticlePubMedPubMed CentralCASGoogle Scholar Gasser, E., Sancar, G., Downes, M. & Evans, R. M. Metabolic messengers: fibroblast growth factor 1.Nat. Metab.4, 663–671 (2022)....
Neurosci Lett. 2017; 653:22-29.2. Hevner RF, et al. FGF17 regulates the genesis of neocortical precursors in the developing forebrain. Neuron. 2003;40(6): 1167-1180.3. Iwakura Y, et al. Roles of FGF signals in heart development, health, and disease. Front Cell Dev Biol. 2016; 4:110...
Early-life determinants are thought to be a major factor in the rapid increase of obesity. However, while maternal nutrition has been extensively studied, the effects of breastfeeding by the infant on the reprogramming of energy balance in childhood and throughout adulthood remain largely unknown. ...
The central roles of members of the fibroblast growth factor (FGF) family in human developmental processes and disease have been well documented. In their Review, Beenken and Mohammadi discuss the more established applications of FGF-related therapies in
Cholesterol gallstone disease (CGD) is accompanied by biliary cholesterol supersaturation. Hepatic Niemann-Pick C1-like 1 (NPC1L1), which is present in humans but not in wild-type (WT) mice, promotes hepatocyte cholesterol uptake and decreases biliary cholesterol supersaturation. In contrast, intestin...