Effect of phosphate binders on serum FGF-23 levels in maintenance hemodialysis patients with hyperphosphatemia目的:近年来,许多研究显示高水平的FGF-23与肾脏疾病进展,心血管病死率及左心室肥厚相关.饮食磷限制及磷结合剂可用来控制磷酸盐平衡及升高的血清FGF-23水平.本研究的目的在于比较碳酸镧和碳酸钙对于维持...
FGF23 mode of action as a phosphatonin The physiologic effect of FGF23 is on phosphate meta- bolism. Although receptors to FGF23 are present in many tissues, only the kidney and parathyroid gland respond to the hormone. The reason is that the phosphaturic actions of FGF23 require FGF ...
Effect of hydrolysis-resistant FGF23-R179Q on dietary phosphate regulation of the renal type-II Na/Pi transporter. Pflugers Arch. 2003;446:585–592. CAS PubMed Google Scholar Segawa H, Yamanaka S, Ohno Y, Onitsuka A, Shiozawa K, Aranami F, Furutani J, Tomoe Y, Ito M, Kuwahata M,...
Although the precise nature of CKD-associated factors and the crosstalk among them and with FGF23 remain elusive, one could envision a synergistic effect between high serum levels of phosphate and FGF23, as has been speculated.8 Feeding studies in mice showing that a high-phosphate diet is ...
肾性磷酸盐消耗综合征(Renal phosphate wasting syndromes)由一组异质性疾病组成,具有多种病因,在生化上表现为低磷酸盐血症。低磷血症的鉴别诊断有很多: 第一步是检查血清磷酸盐水平降低是否是由于肾小管对磷酸盐的重吸收(TRP/ tubular...
Serum phosphate (iP), calcium, Heart and Vessels (2021) 36:414–423 415 and intact parathyroid hormone (iPTH) are proposed to regulate FGF23 levels in uremic patients on maintenance hemodialysis [6], and current data suggest higher circulat- ing levels of FGF23 are associated with mortality ...
Effect of manipulating serum phosphorus with phosphate binder on circulating PTH and FGF23 in renal failure rats Kidney Int, 69 (2006), pp. 531-537 View PDFView articleCrossrefView in ScopusGoogle Scholar 23. A.A. Portale, B.E. Booth, B.P. Halloran, et al. Effect of dietary phosphorus...
To investigate the role and mechanism of fibroblast growth factor 23 (FGF23) in renal interstitial fibrosis.#Rat renal tubular epithelial cell line (NRK-52E) was selected for in vitro experiments. Effect of FGF23 on extracellular matrix was observed. High expression of FGF23 was induced by inje...
Phosphate diabetes is defined as inadequate tubular reabsorption. Hypophosphatemia is responsible for most of the clinical manifestations, which vary with ... M Laroche,JF Boyer - 《Joint Bone Spine Revue Du Rhumatisme》 被引量: 174发表: 2005年 Vitamin D and aging. Recent studies using genetical...
fgfrs细胞分化klothohspgshbgm 硕士学位论文 FGF23/FGFRs调节成骨细胞分化的作用和机制研究 莫奇非 指导教师陈林教授 导师组成员苏楠副教授 培养单位 陆军军医大学陆军特色医学中心 战伤组织修复与康复医学研究室 申请学位类别硕士学术学位专业名称外科学(野战外) 答辩委员会主席罗凌飞教授 答辩委员周元国、谭颖徽、李礼、...