The effect of PTH was prevented by added sclerostin. Therefore, PTH increases FGF23 expression which involves the PKA an Wnt pathways. The effect of PTH on FGF23 completes a bone-parathyroid endocrine feedback loop. Importantly, secondary hyperparathyroidism is essential for the high-FGF23 levels ...
排除甲状旁腺激素(PTH)驱动的肾小管磷酸盐重吸收减少后,应检查肾性磷酸盐消耗的其他两个主要原因:固有肾磷酸盐转运缺陷和成纤维细胞生长因子23 (FGF23)相关原因,如X连锁低磷酸盐血症(XLH)1。 本共识声明将XLH作为肾性磷酸盐消耗的...
(i) they modified the association between the exposition variables PO4 excretion, NAE, or uPRAL and the outcomes FGF23 or α-klotho (i.e., if changes in the β coefficient of predictors were ≥ 10%), (ii) they had an independent and significant effect on the outcome FGF23 (P <...
排除甲状旁腺激素(PTH)驱动的肾小管磷酸盐重吸收减少后,应检查肾性磷酸盐消耗的其他两个主要原因:固有肾磷酸盐转运缺陷和成纤维细胞生长因子23 (FGF23)相关原因,如X连锁低磷酸盐血症(XLH)1。 本共识声明将XLH作为肾性磷酸盐消耗的原因,并会提及获得性肿瘤诱导的骨软化症(TIO)作为鉴别诊断。XLH是一种以佝偻病和...
FGF23 mode of action as a phosphatonin The physiologic effect of FGF23 is on phosphate meta- bolism. Although receptors to FGF23 are present in many tissues, only the kidney and parathyroid gland respond to the hormone. The reason is that the phosphaturic actions of FGF23 require FGF ...
Effect of manipulating serum phosphorus with phosphate binder on circulating PTH and FGF23 in renal failure rats Phosphorus directly controls parathyroid hormone (PTH) synthesis and secretion. Serum levels of the novel phosphate-regulating hormone, fibroblast growth f... N Nagano,S Miyata,M Abe,.....
We next wished to determine the effect of the various identified RGS14 coding-region mutations on basal and PTH-sensitive Pi transport (Fig. 8, C and D). For these studies, we again used OK cells as an RGS14-null model. Under control conditions, PTH inhibited Pi uptake by 60% in OK...
Reduced Renal α-Klotho Expression in CKD Patients and Its Effect on Renal Phosphate Handling and Vitamin D Metabolism Renal α-Klotho (α-KL) plays a fundamental role as a co-receptor for fibroblast growth factor 23 (FGF23), a phosphaturic hormone and regulator of 1,25(OH)... H Sakan,...
In dialysis patients, the calcium effect on FGF23 production is Toxins 2019, 11, 175 5 of 20 more prominent if phosphate is within the normal range [21]. A decrease in calcium below 8 mg/dL diminishes the elevation of FGF23 induced by high phosphate [80,83]. The reduction of PTH ...
塞均可显著降低患者钙,磷,PTH,FGF23水平,且联合用药治疗效果优于单用骨化三醇组,对降低高海拔地区维持性血液透析患者发生高磷血症,继发性甲状旁腺功能进等危险... 马志宏,王玉英,贾顺莲,... - 《高原医学杂志》 被引量: 0发表: 2017年 甲状旁腺切除联合前臂自体移植术对维持性血液透析患者Klotho/FGF23的影响...