Ferroptotic cell death and cancerIsraeli, EitanIsrael Medical Association Journal
总的来说,这些发现确定了HSPA5在铁死亡中的新作用,并提出了克服吉西他滨耐药性的潜在治疗策略。 既往发现erastin诱导铁死亡在KRAS突变的细胞筛选药物时发现的,可以被铁死亡抑制剂抑制,作者在细胞系水平诱导铁死亡发现HSPA5升高。Erastin在癌细胞铁下垂期间触发热休克反应和内质网应激,作者测了相关的蛋白变化,发现了HSPA5和...
因为erastin难溶的特性,作者构建了一个容易溶解的erastin称为PE,通过诱导发现PE和RSL3可以在诱导铁死亡过程中升高,并且具有相对特异性。使用siRNAs敲除GPX4显著增加了PTGS2的基因丰度,而siDeath对PTGS2的基因丰度的影响最小(图6B)。熊谷等人(2004)报道了4-HNE对PTGS2的上调,4-HNE是氧化脂质的终产物。此外,从Gpx4缺陷...
Ferroptosis, a regulated form of cell death triggered by iron-dependent lipid peroxidation, has emerged as a promising therapeutic strategy for cancer treatment, particularly in hepatocellular carcinoma (HCC). However, the mechanisms underlying the regulation of ferroptosis in HCC remain to be unclear....
death and their survival. Cancer is one of them. It is important to note that the development ofcancer cells' resistance tocell deathis directly related to the ineffectiveness of anticancer therapy. Initially, it has been thought that chemo- and radiotherapies induce apoptotic cell death. However...
Ferroptosis is a newly identified iron-dependent form of death that is becoming increasingly recognized as a promising avenue for cancer therapy. N6-methyladenosine (m6A) is the most abundant reversible methylation modification in mRNA contributing to tu
However, during anticancer therapy, tumor cells acquire mutations that make cancer cells resistant to apoptosis, a type of cell death most often triggered by modern chemo and radiotherapy. This leads to a decrease in the effectiveness of treatment and the progression of cancer. In this case, it...
Ferroptosis, a form of iron-dependent cell death driven by cellular metabolism and iron-dependent lipid peroxidation, has been implicated as a tumor-suppressor function for cancer therapy. Recent advance revealed that the sensitivity to ferroptosis is tightly linked to numerous biological processes, ...
Ferroptosis is a form of regulated cell death driven by oxidative injury promoting lipid peroxidation, although detailed molecular regulators are largely unknown. Here, we show that heatshock 70-kDa protein 5 (HSPA5) negatively regulates ferroptosis in human pancreatic ductal adenocarcinoma (PDAC) cells...
Sensitivity profiling in 177 cancer cell lines revealed that diffuse large B cell lymphomas and renal cell carcinomas are particularly susceptible to GPX4-regulated ferroptosis. Thus, GPX4 is an essential regulator of ferroptotic cancer cell death. Graphical Abstract Download: Download high-res image ...