FerroptosisCancer stem cellsCancer resistanceNRF2YAP/TAZCD44AutophagyResistance to chemotherapeutic agents remains a major challenge in the fierce battle against cancer. Cancer stem cells (CSCs) are a small population of cells in tumors that possesses the ability to self-renew, initiate tumors, and ...
ResearchOpen Access30 Apr 2025Signal Transduction and Targeted Therapy Volume: 10, P: 145 SETD5 facilitates stemness and represses ferroptosis via m6A-mediating PKM2 stabilization in non-small cell lung cancer Xingzhe Liu Yuzhen Cui Yanhua Xuan ...
DKK1 also significantly reduced ferroptosis-specific lipid peroxidation and induced a ferroptosis-resistant cell state. Thus, blockade of DKK1 combined with induction of ferroptosis may be a potential therapeutic strategy to limit metastatic disease. Results BCSC secretome compresses the stem cell pool To...
Targeted activation of ferroptosis in colorectal cancer viaLGR4targeting overcomes acquired drug resistance 中文标题 针对性激活肿瘤细胞铁死亡途径克服结直肠癌中的获得性药物耐药性 基本信息 发表日期:2024-01-30 文章类型:Article 文章作者:Hao Zheng | Jinming Liu | Qi Cheng | Qianping Zhang | Yaoyao Zhang...
Ferroptosis is a novel type of cell death with distinct properties and recognizing functions involved in physical conditions or various diseases including cancers. The fast-growing studies of ferroptosis in cancer have boosted a perspective for its usage in cancer therapeutics. Here, we review the cur...
Ferroptosis is a new form of regulated cell death that is dependent on iron- and lipid reactive oxygen species. Emerging evidence indicate that induction of ferroptosis could inhibit the proliferation of diverse cancer cells, which functions as a potent tumor suppressor in cancer. Here, we firstly...
Cancer metabolism mainly includes carbohydrate, amino acid and lipid metabolism, each of which can be reprogrammed. These processes interact with each other to adapt to the complicated microenvironment. Ferroptosis is a regulated cell death induced by iron-dependent lipid peroxidation, which is morphologi...
[22]Zhang T, Sun LC, Hao YJ, et al. ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1. Nat Cancer. 2021; 3(1): 75-89. [23]Liu Q, Li J, Zhang W, et al. Glycogen accumulation and phase separation drives liver tumor initiation. Cell. 2021...
英文题目:Circular RNA-encoded oncogenic PIAS1 variant blocks immunogenic ferroptosis by modulating the balance between SUMOylation and phosphorylation of STAT1 Article 一、文章导读 黑色素瘤(Melanoma)是一种来源于黑素细胞恶性转变的肿瘤,其具有较高的致死率,严重危害人类健康。近年研究表明,免疫检查点阻断剂(...
Lipid-degrading small molecule kills cancer cells by ferroptosis A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer. Mike Lange &James A. Olzmann ...