The discovery of ferroptosis stemmed from the high-throughput screening of small molecules aimed at targeting oncogenic RAS mutations. In 2003, erastin was identified as a selective inducer of non-apoptotic cell death in cancer cells dependent on ST- and RASG12V,39along with the involvement of th...
To sum up, arenobufagin promotes autophagy-dependent ferroptosis of HepG2 cells by inducing autophagy and regulating p62-Keap1-Nrf2 pathway. It is suggested that arenobufagin can be used as a potential intervention therapy.doi:10.1007/s00210-023-02916-5...
& Tang, D. Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death. Cancer Gene Ther. 28, 55–63 (2021). CAS PubMed Google Scholar Prior, I. A., Lewis, P. D. & Mattos, C. A comprehensive survey of Ras mutations in cancer. Cancer Res....
Programmed cell death (PCD) is a kind of RCD that can be activated by external factors such as pathogens or drugs and is tightly regulated by a number of intracellular molecules and pathways [13]. Pyroptosis, ferroptosis, and autophagy are three newly discovered types of PCD that are being ...
Cross-talk between ferroptosis, apoptotic, and autophagy in cancer. Autophagy can modulate cell sensitivity to ferroptosis through various pathways. Erastin, artesunate, MON-P53, and Cys closely link ferroptosis with apoptosis. ELAVL1 promoted autophagy by binding to the AU-rich elements within the F3...
What effect does PM2.5 treatment have on autophagy and p62 accumulation? How does PM2.5 exposure affect lysosomal function and pH levels? What effect does Nrf2 inhibition have on cell viability after PM2.5 exposure? What is the relationship between autophagy and ferroptosis in the context of PM2.5...
Ferroptosisis a type of cell death that is morphologically, biochemically, and genetically distinct fromapoptosis, necrosis, and autophagy[14]. In terms of morphological changes,ferroptosisis characterized by mitochondrial atrophy, reduction or disappearance of mitochondrialcristae, increase ofmitochondrial me...
Regulated cell death is indispensable for maintaining normal physiological homeostasis, and either excessive or insufficient cell death can lead to the initiation of diseases[4]. Emerging evidence indicates that multiple forms of cell death, including apoptosis, autophagy, necroptosis and pyroptosis[5], ...
In vivo autophagy inhibition and apoptosis and ferroptosis enhancement are involved in the anticancer effect of combined melatonin and erastin treatment To further verify the underlying mechanisms by which melatonin and erastin exert anticancer effects in vivo, cell apoptosis and autophagy were evaluated. ...
Ferroptosis and autophagy are two main forms of regulated cell death (RCD). Ferroptosis is a newly identified RCD driven by iron accumulation and lipid peroxidation. Autophagy is a self-degradation system through membrane rearrangement. Autophagy regulates the metabolic balance between synthesis, degradati...