Ferroptosis suppressor protein 1 (FSP1)/CoQ10, dihydroorotate dehydrogenase (DHODH), and GTP cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH4) act independent of GPX4 to suppress ferroptosis. In 1956, CoQ10, originally known as vitamin Q10 or ubiquinone due to its vitamin-like structure and ...
BH4是一种颇具实力的自由基捕获抗氧化剂,但它的回收再利用需要二氢叶酸还原酶DHFR的参与,因此如果阻断二氢叶酸还原酶DHFR,则可协同GPX4抑制剂发挥诱导铁死亡的作用。 除此以外,BH4还可以通过将苯丙氨酸转化为酪氨酸来促进CoQ10的合成,这是它发挥抗氧化作用的另一种方式。目前,GCH1/BH4/DHFR系统在铁死亡中的潜在生...
The top 10 countries ranked on the basis of the number of publications and citations are presented in Table 3. China, as the most prolific country, accounted for 47.03% of the total number of articles published. Germany and the USA were also at the top of the list of the average number...
Exosome-regulated ferroptosis by the NAD(P)H/FSP1/CoQ10 system and its application in treating diseases The role of the NAD(P)H/FSP1/CoQ10 system in ferroptosis Ferroptosis inhibitor protein 1 (FSP1) is a key protein that protects against ferroptosis. FSP1 knockout cell lines are more sen...
(HMG-CoA) reductase activity, can also increase the rate of ferroptosis by depleting cellular CoQ10 [61]. Researchers investigating how cells prevent ferroptosis in the absence of GPX4 discovered the flavoprotein apoptosis-inducing factor mitochondria-associated 2 (AIFM2), subsequently renamed FSP1. ...
Ferroptosis is a newly defined form of regulated cell death (RCD) characterized by iron overload, lipid reactive oxygen species (ROS) accumulation, and lipid peroxidation, which is different from necrosis, apoptosis, autophagy and other forms of RCD in morphology, biochemistry, function and gene ex...
causing the release of its contents and triggering an intense inflammatory response [9,10]. Autophagy plays a key role in cell and tissue homeostasis. Many stimuli, such as nutrient deficiency, oxidative stress, and protein aggregation, can kick-start autophagy. It can be divided into three subt...
Special issue Ferroptosis: Crosstalk between metabolism and biochemical homeostasis Last update 18 February 2025Actions for selected articles Select all / Deselect allDownload PDFsExport citations Show all article previewsShow all article previews
Class 3: degrade GPX4, bind to SQS and deplete antioxidant CoQ10 A member of the third category is FIN56, which has two ways to induce ferroptosis. First, FIN56 stimulates the degrading of GPX4. Second, FIN56 binds to the squalene synthase enzyme, which causes the endogenous antioxidant coe...
CoQ10 (Coenzyme Q10) is an essential fat-soluble metabolite that plays a key role in cellular metabolism. A less-known function of CoQ10 is whether it may act as a plasma membrane-stabilizing agent and whether this property can affect cancer development