Brent R Stockwell 在Cell(IF= 66.85)上发表了题为《Ferroptosis turns 10:Emerging mechanisms, physiological functions, and therapeutic applications(铁死亡的十年:新兴机制、生理功能,及其治疗应用)》的重磅综述。该综述从细胞代谢、活性氧生物学和铁生物学等方面系统阐述了铁死亡的关键调控因子,重点介绍了铁死亡领域...
Exosome-regulated ferroptosis by the NAD(P)H/FSP1/CoQ10 system and its application in treating diseases The role of the NAD(P)H/FSP1/CoQ10 system in ferroptosis Ferroptosis inhibitor protein 1 (FSP1) is a key protein that protects against ferroptosis. FSP1 knockout cell lines are more sen...
The top 10 countries ranked on the basis of the number of publications and citations are presented in Table 3. China, as the most prolific country, accounted for 47.03% of the total number of articles published. Germany and the USA were also at the top of the list of the average number...
WZ performed the experiments, analyzed the data, and wrote the manuscript; FW performed the experiments; ZC performed the experiments; YZ performed the experiments; YL performed the experiments; NL performed the experiments; ZM performed the experiments; HZ performed the experiments; YL performed the ...
Ferroptosis is a newly defined form of regulated cell death (RCD) characterized by iron overload, lipid reactive oxygen species (ROS) accumulation, and lipid peroxidation, which is different from necrosis, apoptosis, autophagy and other forms of RCD in morphology, biochemistry, function and gene ex...
When SOX10 was downregulated or CMTM7 was overexpressed, it notably hindered the cells' activity, while also promoting cell apoptosis in vitro. Meanwhile, CMTM7 is regulated by SOX10 in the downstream, and its silencing significantly reversed the inhibition of sh-SOX10 on PANC-1 cells growth...
(HMG-CoA) reductase activity, can also increase the rate of ferroptosis by depleting cellular CoQ10 [61]. Researchers investigating how cells prevent ferroptosis in the absence of GPX4 discovered the flavoprotein apoptosis-inducing factor mitochondria-associated 2 (AIFM2), subsequently renamed FSP1. ...
Osteoarthritis (OA) is a widespread joint disorder that is primarily noted for the progressive degeneration of joint cartilage, accompanied by a significant inflammatory response. Recently, there has been a growing interest in understanding the roles of ATF3 and ferritin-related RNAs in the context ...
摘要 Ferroptosis是近年发现的调控细胞死亡的方式,在生化、基因和形态学等方面与其他形式的细胞死亡有显著的差异.Ferroptosis过程受严格而复杂的调控机制控制,其特点是,脂质过氧化物和致死的活性氧(reactive oxyge... 关键词铁代谢 / 活性...
Class 3: degrade GPX4, bind to SQS and deplete antioxidant CoQ10 A member of the third category is FIN56, which has two ways to induce ferroptosis. First, FIN56 stimulates the degrading of GPX4. Second, FIN56 binds to the squalene synthase enzyme, which causes the endogenous antioxidant coe...