(1) develop better treatments or prevention strategies for AD, or, as a strategy to identify subpopulations at risk for developing AD, or (2) resolve clinically difficult differential diagnoses (e.g., frontotemporal dementia (FTD) versus AD) where the use of PET Aβimaging appears to improv...
Lieberman and T. Tasdizen, "Automatic classification of Alzheimer's Disease vs. Frontotemporal dementia: A spatial decision tree approach with FDG-PET", 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Paris, France, May 14 - 19, 2008, pp...
FDG PET scans (first row) and MRI co-registration of two preclinical early-onset FAD siblings with the APP 717 Val-Ile mutation.Case 1a 60-year-old male with deficits in short- and long-term memory and in visuospatial and executive functions showed mild parietal and hippocampal atrophy associa...
25,26]. For example, FDG-PET can be assessed using software that analyses the pattern of tracer uptake voxel-wise by comparing the subject’s scan with a reference data set of normal ageing, allowing a better recognition of the patterns of hypometabolism compared ...
Distinguishing Alzheimer's disease (AD) and frontotemporal dementia (FTD) currently relies on a clinical history and examination, but positron emission tomography with [(18)F] fluorodeoxyglucose (FDG-PET) shows different patterns of hypometabolism in these disorders that might aid differential diagnosis....
Foster NL. Validating FDG-PET as a biomarker for frontotemporal dementia. Exp Neurol 2003;184: S2-S8.Foster NL (2003) Validating FDG-PET as a biomarker for frontotemporal dementia. Exp Neurol 184(Suppl 1):S2–S8Validating FDG-PET as a biomarker for frontotemporal dementia. Exp Neurol 2003b ...
242195 Introduction: Frontotemporal Dementia (FTD) comprises a diverse set of neurodegenerative conditions marked by progressive degeneration of the frontal and temporal lobes of the brain, manifesting in varied behavioral, linguistic, and motor disturbances. FDG PET imaging of the thalamus frequently ...
FDG-PETFrontotemporal dementiaHypometabolismBackground and objective Reserve is defined as the ability to maintain cognitive functions relatively well at a given level of pathology. Early life experiences such as education are associated with lower dementia risk in general. However, whether more years of...
18F-FDG PET find- ings in frontotemporal dementia: an SPM analysis of 29 patients. J Nucl Med 2005; 46: 233-239.Jeong Y, Cho SS, Park JM , et al.: 18F-FDG PET findings in frontotemporal dementia: an SPM analysis of 29 patients. J Nucl Med. 2005, 46:233-9....
Methods. All patients were evaluated with a neuropsychological battery followed by 18F-FDG-PET scan, in addition to all necessary dementia work-up. Results. 15 FTD patients (m:f = 11:4) had a mean age of presentation of 67.4 (8.6) years, with a mean interval of 1.7 (...