Fatty acid oxidationPeroxisomal diseasesInterorganellar crosstalkRedox shuttlesPorinsABC transportersBile acidsGenetic diseasesFatty acidsPeroxisomes play a central role in metabolism as exemplified by the fact that many genetic disorders in humans have been identified through the years in which there is an ...
Peroxisomal b-oxidation is reserved for very long-chain fatty acids (C20 or longer), that are poorly handled by mitochondria. Oxidation is uncoupled from phosphorylation in peroxisomes. Cytoplasmic malonyl-CoA inhibits the rate-limiting enzyme in fatty acid oxidation....
Thus fatty acid oxidation can occur in the mitochondria, peroxisomes, and ER. Under an excessive flux of FFAs and elevated insulin resistance, oxidation of long-chain and very-long-chain fatty acids in peroxisomes and ER leads to an overproduction of ROS and lipotoxicity [93]. The principal ...
D. Level of fatty acid synthesis Answer: B 8. Where else in the cell does β-oxidation occur, apart from the mitochondria? A. Cytoplasm B. Nucleus C. Peroxisomes D. Endoplasmic reticulum Answer: C 9. What is the fate of excess acetyl-CoA when glucose metabolism is not optimal? A. It...
The importance of peroxisomes for humans is stressed by the existence of a group of genetic diseases in humans in which there is an impairment in one or more peroxisomal functions. Most of these functions have to do with lipid metabolism including the alpha- and beta-oxidation of fatty acids....
The peroxisomal acyl-CoA oxidase and enoyl-CoA hydratase-beta-hydroxyacyl-CoA... 关键词: FATTY ACID OXIDATION PEROXISOMAL OXIDATION DOI: 10.1111/j.1530-0277.1986.tb05182.x 被引量: 800 年份: 1978 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 全文购买 Wiley 万方医学 Semantic ...
VLCFA beta-oxidation in peroxisomes occurs by a process similar to mitochondrial beta-oxidation; however, some key differences exist, including the fact that different genes encode fatty acid oxidation enzymes in peroxisomes, which is significant in certain inborn errors of metabolism.[7]The enzyme re...
Therefore, peroxisomal β -oxidation is assayed by measuring acyl-CoA-or fatty acid-dependent, KCN-insensitive acetyl-CoA production or NADH formation. Peroxisomal β -0xidation is discovered in glyoxysomes, which are organelles found only in fat-storing tissues of germinating seeds. The peroxisome...
Chapter 5 Fatty acid oxidation and its regulation 1984, New Comprehensive Biochemistry Changes in coa pools in hepatic peroxisomes of the rat, under various conditions 1986, Journal of Biochemistry PEROXISOMAL βT‐OXIDATION OF LONG FATTY ACIDS: EFFECTS OF HIGH FAT DIETS ...
The enzymatic apparatus of fatty acid β-oxidation in peroxisomes and glyoxysomes includes a multifunctional protein. Two forms of this protein were detected in extracts from cotyledons of germinating cucumber seeds and separated on hydroxylapatite. The two proteins purified to apparent homogeneity posse...