1982. Peroxisomal oxidation of fatty acids in livers of rainbow trout (Salmo gairdneri) fed diets of marine zooplankton. Comp. Biochem. Physiol. B Comp. Biochem. 73: 565-570.H E N D E R S O N . R . J . , S A R G E N T J . R . A N D PIRIE,B.J.S. 1982. ...
The only known source of unlabeled extramitochondrial acetyl-CoA (in the absence of exogenous acetate) is the partial peroxisomal oxidation of fatty acids. Although [1-13C]oleate was M1-labeled in its first acetyl, its oxidation did not generate any M2 acetyl-CoA. Therefore, all acetyl-CoA ...
The importance of peroxisomes for humans is stressed by the existence of a group of genetic diseases in humans in which there is an impairment in one or more peroxisomal functions. Most of these functions have to do with lipid metabolism including the alpha- and beta-oxidation of fatty acids....
A cell organelle containing a large number of enzymes, including catalase and oxidase, that break down long-chain fatty acids and other organic molecules. The hydrogen peroxide produced by these reactions is also broken down within the peroxisome. ...
The biochemical findings are brought about by insufficiency in such metabolic functions as oxidation of fatty acids with very long chains, oxidation of the phytanic and pipecolic acids, synthesis of cholesterol, bile salts and plasmalogenes. Rhizomelic chondrodysplasia punctata and Zellweger's syndrome ...
In both organelles, degradation of straight-chain saturated fatty acids requires the participation of the four activities comprising the core of the β-oxidation cycle, namely acyl-CoA dehydrogenase in mitochondria or acyl-CoA oxidase in peroxisomes, enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase...
Long-chain acyl-CoA levels in liver from rats fed high-fat diets: Is it of significance for an increased peroxisomal β-oxidation? 1984, Lipids MITOCHONDRIAL AND PEROXISOMAL β‐OXIDATION OF FATTY ACIDS IN RAT LIVER 1982, Annals of the New York Academy of Sciences LEAF PEROXISOMES 1982, Annals...
In mammals, peroxisomes are involved in breakdown of very long chain fatty acids, prostanoids, pristanic acid, dicarboxylic fatty acids, certain xenobiotics and bile acid intermediates. Substrate spectrum and specificity studies of the four different β-oxidation steps in rat and/or in man demonstrat...
Peroxisomes play an important role in a variety of metabolic pathways, including the α‐ and β‐oxidation of fatty acids, and the biosynthesis of ether phospholipids. Single peroxisomal enzyme deficiencies (PEDs) are a group of peroxisomal disorders in which either a peroxisomal matrix enzyme or ...
We investigated the peroxisomal β -oxidation system in liver from a patient with clinical features similar to those in the cerebrohepatorenal (Zellweger) syndrome and with elevated levels in body fluids of very-long-chain fatty acids and intermediates in the biosynthesis of bile acids. The peroxiso...