beta-Oxidation occurs in both mitochondria and peroxisomes. Mitochondria catalyze the beta-oxidation of the bulk of short-, medium-, and long-chain fatty acids derived from diet, and this pathway constitutes the major process by which fatty acids are oxidized to generate energy. Peroxis...
PEROXISOMAL {beta}-OXIDATION AND PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR {{alpha}}: An Adaptive Metabolic System.Focuses on the developments in the enzymology and functional organization of peroxisomal beta-oxidation pathways and provides the perspectives on the critical importance of peroxisome ...
Karpichev IV, Luo Y, Marians RC, Small GM (1997) A complex containing two transcription factors regulates peroxisome proliferation and the coordinate induction of beta-oxidation enzymes inSaccharomyces cerevisiae. Mol Cell Biol 17:69–80 PubMedCASGoogle Scholar Kasai H, Okada Y, Nishimura S, Rao...
Peroxisomesare single-membrane lined organelles present in alleukaryotic cells, which catalyze a range of essential metabolic functions, such as beta-oxidation of very long-chain fatty acids (VLCFA), branched-chain fatty acids andbile acids,phytanic acidalpha-oxidation,plasmalogensynthesis,cholesterol synt...
Peroxisome proliferators function as ligands for the peroxisome proliferator-activated receptor [alpha] (PPAR[alpha]) (Issemann and Green 1990), a nuclear receptor that regulates genes involved in fatty acid transport and [beta]-oxidation, resulting in increased fatty acid catabolism and increases in...
beta-Oxidation occurs in both mitochondria and peroxisomes. Mitochondria catalyze the beta-oxidation of the bulk of short-, medium-, and long-chain fatty a... JK Reddy,T Hashimoto - 《Annual Review of Nutrition》 被引量: 2162发表: 2001年 Activation of peroxisome proliferator-activated receptor ...
Peroxisomes are highly dynamic, oxidative organelles with key metabolic functions in cellular lipid metabolism, such as the β-oxidation of fatty acids
Peroxisomes contain a classical L-hydroxy-specific peroxisome proliferator-inducible beta-oxidation system and also a second noninducible D-hydroxy-specific beta-oxidation system. We previously generated mice lacking fatty acyl-CoA oxida... C Qi,Y Zhu,J Pan,... - 《Journal of Biological Chemistry...
In contrast to mitochondria, FADH2 produced during peroxisomal beta-oxidation is converted into hydrogen peroxide whereas in mitochondria FADH2 is used to generate ATP [64,65]. Mitochondria and peroxisome are metabolically connected, with mitochondria serving as source of many peroxisomal enzymes and ...
Peroxisomes are key metabolic organelles, which contribute to cellular lipid metabolism, e.g. the β-oxidation of fatty acids and the synthesis of myel