FA2HFatty acid 2-hydroxylaseMDA-MB-231 cellsPPARαPeroxisome proliferator-activated receptor αThe functional role of fatty acid 2-hydroxylase (FA2H) is controversial in the field of cancer biology due to the dual role of FA2H, particularly related to its interaction with triple-negative breast...
Fatty acidhydroxylaseis required for the formation of 2-hydroxy fatty acids(hFA) (Alderson et al., 2004; Eckhardt et al., 2005), which are among the most important building blocks ofsphingolipidsin mammals (for review seeHama, 2010). Based on this it is likely that mutations inFA2Haffect...
FA 2-hydroxylase (FA2H) is an NAD(P)H-dependent enzyme that initiates FA α oxidation and is also responsible for the biosynthesis of 2-hydroxy FA (2-OH FA)-containing sphingolipids in mammalian cells. The 2-OH FA is chiral due to the asymmetric carbon bearing the hydroxyl group. Our ...
Mutations in the fatty acid 2-hydroxylase gene, FA2H, have been associated with leukodystrophy and spastic paraparesis in humans, underscoring the importance... H Hama - BBA - Molecular and Cell Biology of Lipids 被引量: 200发表: 2010年 Hereditary adult-onset Alexander's disease with palatal ...
Fatty Acid 2-Hydroxylase 来源宿主 兔 反应性 人,小鼠,大鼠 保存建议 建议收到该Fatty Acid 2-Hydroxylase (FA2H) Antibody产品后,储存温度为-20°C。避免重复冻融 其他 Abbexa总部位于英国剑桥的剑桥科学园,是一家专业的全球抗体供应商和蛋白质供应商,致力于为生命科学、药物开发和生物技术领域的科学家和研究者...
Normal Fur Development and Sebum Production Depends on Fatty Acid 2-Hydroxylase Expression in Sebaceous Glands.doi:10.1074/jbc.M111.2319772-Hydroxylated fatty acid (HFA)-containing sphingolipids are abundant in mammalian skin and are believed to play a role in the formation of the epidermal barrier....
located thessc-mir-103-2gene, which is transcribed into the miR-103-2 microRNA. In adipocytes, miR-103 accelerates adipogenesis and increases the expression of lipid metabolism related genes such as fatty acid binding protein 4 (FABP4) and adiponectin, C1Q and collagen domain containing (ADIPOQ...
This chapter describes the purification procedure of fatty acid ω-hydroxylase (alkane hydroxylase) from Pseudomonas oleovorans. The hydroxylation system induced in Pseudomonas oleovorans by growth on alkanes contains three proteins: NADH-rubredoxin reductase—a flavoprotein containing one molecule of flav...
The fatty acid 2-hydroxylase (FA2H) is essential for synthesis of 2-hydroxylated fatty acids in myelinating and other cells, and deficiency of this enzyme causes a complicated form of hereditary spastic paraplegia also known as fatty acid hydroxylase-associated neurodegeneration. Despite its important...
The invention provides isolated nucleic acid molecules which encode novel fatty acid hydroxylases. The invention also provides recombinant expression vectors including hydroxylase n