ProteinS-acylation is a reversible post-translational lipid modification that involves linkage of a fatty acid chain predominantly to a cysteine amino acid via a thioester bond. The fatty acid molecule is primarily palmitate, thus the term ‘palmitoylation’ is more commonly used. Palmitoylation has b...
Q.; Zeng, F.; Liu, X.; Wang, Q. J.; Deng, F. Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer.Cell death & disease2016,7, e2226.
Palmitoylethanolamide (PEA) is a fatty molecule that is produced in small amounts with the body, mostly in response to tissue damage or tissue or muscle injury. PEA is naturally produced by the body’s immune system in response to pain or inflammation. Palmitoylethanolamide, also known as ...
Molecular models of the two parasite proteins showed that both molecules adopt the same basic three-dimensional structure, consisting of a barrel-shaped molecule formed by 10 antiparallel β -pleated strands joined by short loops, and revealed the likely presence of crossreactive, discontinuous ...
Obviously, this “promiscuous” nature, which is more often seen with fatty acid amides [17] will have contributed to its initially slow development. It has now become clear that PEA is a highly abundant signalling molecule reaching concentrations in brain and peripheral tissues as high or even...
Palmitoylethanolamide (PEA) is a fatty acid amide molecule involved in a variety of cellular functions in chronic pain and inflammation. It has been shown to have neuroprotective, anti-inflammatory, anti-nociceptive (antipain) and anti-convulsant properties. Often in people with chronic disorders,...
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HOMO and LUMO are known as "FMOs" and are defined by donating/accepting electrons, respectively, which may determine the path binding of fatty acid with a steel surface59,60,61. The FMO gap is used to measure a molecule's chemical reactivity and kinetic stability. Raising the inhibitor's ...
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With the increasing interest in health and nutrition for longevity of life and more performance ability, the idea of health foods and nutrients has attracted more research and studies. Omega-3 fatty acid docosahexaenoic acid (DHA) is a nutrient molecule