HBP integrates carbohydrates (glucose), amino acids (glutamine), lipids (acetyl-CoA), and nucleotides (UTP), culminating in the generation of UDP-GlcNAC, a substrate for O-GlcNAcylation reactions by OGA/OGT. Signaling by mTOR...
[234] and lipid accumulation are the diversion of acetyl-CoA, The progressive isoenzyme shift from glucokinase a substrate of acetyl-CoA carboxylase and of the Krebs Hepatobiliary Pancreat Dis Int,Vol 16,No 6 • December 15,2017 • www.hbpdint.com • 585 Hepatobiliary & Pancreatic Diseases...
Metabolism: A metabolic switch of fateFatty acid oxidation and increased acetyl-CoA levels act to suppress endothelial–mesenchymal transition.doi:10.1038/nrm.2018.14StrzyzPaulinaNature Reviews Molecular Cell Biology
The resulting acetyl CoA is then catabolized in the glyoxylate cycle into organic acids that are further processed into sugars that can fuel seedling growth. 年份: 2013 收藏 引用 批量引用 报错 分享 全部来源 求助全文 掌桥科研 相似文献Out with the Old: The Fate of Obsolete Peroxisomes....
acidification. In anaerobic digestion, proteins and polysaccharides are first hydrolyzed into amino acids and monosaccharides by proteases and α-glucosidases, respectively. The resulting amino acids are converted to SCFAs by BK and acetyl-CoA is translated into acetic acid by AK. Finally, methylation...
of cellular metabolism, most notablyS-adenosylmethionine and acetyl-CoA, which serve as the donors formethylationandacetylationmodifications, respectively.Enzymesthat remove these modifications often also require metabolites as critical cosubstrates. Accordingly, fluctuations in the availability of key ...
Acetyl-CoA is generated from glycolysis, and fatty acid oxidation is catabolized by the tricarboxylic acid cycle (TCA) cycle and oxidative phosphorylation (OXPHOS) in normal cells' mitochondria to make ATP. Through the well-known Warburg effect, cancer cells, unlike normal cells, increase the ...
While both carbohydrate and fatty acid oxidation generate mitochondrial acetyl-CoA and ultimately ATP in mitochondria, the simplest interpretation of these data is that pyruvate and fatty acid oxidation have opposing effects on stem cell homeostasis. Enhanced pyruvate oxidation decreases stem cell maintenanc...
The first reaction involves the conversion of intermediate molecules (pyruvate and fatty acids) into acetyl-CoA, which enters the tricarboxylic acid cycle, yielding free electrons that are carried by NADH and FADH2. In the second reaction, electrons from NADH and FADH2 are transferred to the ...
HBP integrates carbohydrates (glucose), amino acids (glutamine), lipids (acetyl-CoA), and nucleotides (UTP), culminating in the generation of UDP-GlcNAC, a substrate for O-GlcNAcylation reactions by OGA/OGT. Signaling by mTORC1 and AMPK is regulated by concentrations of glucose and amino acids...