Abdel-aleem S, Nada MA, Sayed-Ahmed M, Hendrichson SC, St Louis J, Walthall HP, Lowe JE: Regulation of fatty acid oxidation by acetylCoA generated from glucose utilization in isolated myocytes. J Mol Cell Cardiol 28: 825–833, 1996...
Biomedical Importance •Fatty acids are oxidized to acetyl CoA and synthesized from acetyl CoA –Different parts of cells and different coenzymes are used •Increased fatty acid oxidation leads to ketone body synthesis (ketosis) by the liver during low carb diets, starvation and Type I diabetes...
题目Synthesis of fatty acidsfrom acetyl CoA A. need NADPH B. need NAD+ C. produce malonyl CoAin the first step D. occur in mitochondria E. It's the reverse reactionsoffatty acidoxidation 相关知识点: 试题来源: 解析 AC 反馈 收藏
Fatty acid oxidation refers to the conversion of fatty acids into a utilizable form to produce energy. It is the conversion of fatty acids to acetyl CoA which is used to produce energy. What are the steps of fatty acid oxidation?
The acetyl-CoA generated enters in the Krebs cycle for oxidation, or is converted to ketone bodies such as acetoacetate, d-β-hydroxybutyrate, and acetone, used as energy fuel for several extrahepatic tissues including the brain [94]. Furthermore, the fatty acid oxidation process is regulated ...
17. What occurs in the second stage of fatty acid oxidation? A. Conversion of acetyl-CoA into glucose B. Oxidation of acetyl-CoA to CO2 in the citric acid cycle C. Conversion of acetyl-CoA into ketone bodies D. Hydrolysis of acetyl-CoA Answer: B 18. How does malonyl-CoA affect fatty...
in the form of Acyl-CoA molecules, are broken down in mitochondria and/or in peroxisomes to generate Acetyl-CoA, the entry molecule for the Citric Acid cycle. It occurs in many tissues including liver kidney and heart. Fatty acids oxidation doesn't occur in the brain, as fatty acid can'...
OXIDATION Part 1 – activation and transport Acetyl CoA synthetase (ER or outer mitochondrial membrane) CPT I CPT II Translocase • Carnitine AKA -hydroxy -trimethyl aminobutyric acid • Enzymes are inside the inner membrane of the mitochondria/mitochondrial matrix • Impermeable to CoA and ...
One possible explanation for this low rate of fatty acid oxidation during the suckling period is the dilution of the palmityl-CoA isotope by increased endogenous pools of fatty acids. The increase in fatty acid oxidation at the time of weaning could then be secondary to a decrease in ...
Here, we found that a high-fat diet (HFD) enhanced mitochondrial fatty acid β-oxidation, which enhanced acetyl-CoA levels in the liver of the large yellow croaker. The HFD activated ACLY to govern the "citrate transport" to transfer acetyl-CoA from the mitochondria to the nucleus. Elevated...