Sharkova has purified acetyl-CoA synthetase from rabbit heart by the earlier method to a specific activity of 12 渭moles/min/mg at 37掳.doi:10.1016/S1874-6047(08)60146-8John C. LondesboroughLeslie T. Webster JrELSEVIEREnzymesLondesborough JC, Webster LTJ (1974) Fatty Acyl-CoA synthetases. ...
Long-chain fatty acids (LCFAs) play important roles in cellular energy metabolism, acting as both an important energy source and signalling molecules1. LCFA-CoA esters promote their own oxidation by acting as allosteric inhibitors of acetyl-CoA carboxyla
This substrate flexibility extends further such that these proteins also efficiently utilize N-acetyl cysteamine, the shorter acceptor terminal portion of CoASH, to produce acyl-SNACs. We show that the in situ generated acyl-CoAs and acyl-SNACs could be channeled to types I and -III PKS systems...
This strongly suggests that the target of all 4 herbicides (free-acid form) is the acetyl-CoA carboxylase within the chloroplasts. The applied ester derivatives, in turn, which are ineffective in the isolated chloroplast test system, have equally little or no effect on the activity of the ...
For fatty acid synthesis pathway to function as regulator of energy balance in human hypothalamus, acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS) and other lipogenic enzymes activities must be present. The presence of FAS in human hypothalamic neurons has been shown by immunohistochemistry,...
体内、外模型证实枸杞多糖通过激活沉默信息调节因子1(silent information regulator of tranion 1,SIRT1)/肝激酶B1(liver kinase B1,LKB1)/AMPK通路增加乙酰辅酶A羧化酶(acetyl CoA carboxylase,ACC)磷酸化和脂肪三酰甘油脂肪酶(adipose triglyceride lipase,ATGL)蛋白表达,并降低脂肪酸合酶(fatty acid synthase,FAS)...
Acetyl-CoA carboxylase (ACCase) catalyses the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation. In Arabidopsis thaliana, ACC1 and ACC2, two genes locate...
The reductase activity was susceptible to inhibition by several sulfhydryl reagents; it was lost when the synthase was dissociated into one-half molecular weight subunits or when the incubation mixture was depleted of CoA. It was competitively inhibited by acetyl-CoA, butyryl-CoA, methylmalonyl-CoA,...
In the mitochondria, FAO is characterized by a series of breakdown reactions catalyzed by four major enzymes encoded by ACADM, ECHS1, HADH/HADHA/HADHB, and ACAA2, which results in the generation of acetyl-CoA, NADH, and FADH2. Recent studies have shown that blocking of FAO inhibits tumor ...
This modification will be combined with modifications of core fatty acid elongation, such as overexpression of acetyl-CoA synthetase Acs1p in an attempt to improve fatty acid production rate. Essential for this work is to gain a deeper understanding of the dynamics of fatty acid synthesis and ...