Sharkova has purified acetyl-CoA synthetase from rabbit heart by the earlier method to a specific activity of 12 渭moles/min/mg at 37掳.doi:10.1016/S1874-6047(08)60146-8John C. LondesboroughLeslie T. Webster JrELSEVIEREnzymesLondesborough JC, Webster LTJ (1974) Fatty Acyl-CoA synthetases. ...
LCFA-CoA esters promote their own oxidation by acting as allosteric inhibitors of acetyl-CoA carboxylase, which reduces the production of malonyl-CoA and relieves inhibition of carnitine palmitoyl-transferase 1, thereby promoting LCFA-CoA transport into the mitochondria for β-oxidation2,3,4,5,6....
This substrate flexibility extends further such that these proteins also efficiently utilize N-acetyl cysteamine, the shorter acceptor terminal portion of CoASH, to produce acyl-SNACs. We show that the in situ generated acyl-CoAs and acyl-SNACs could be channeled to types I and -III PKS systems...
This strongly suggests that the target of all 4 herbicides (free-acid form) is the acetyl-CoA carboxylase within the chloroplasts. The applied ester derivatives, in turn, which are ineffective in the isolated chloroplast test system, have equally little or no effect on the activity of the ...
For fatty acid synthesis pathway to function as regulator of energy balance in human hypothalamus, acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS) and other lipogenic enzymes activities must be present. The presence of FAS in human hypothalamic neurons has been shown by immunohistochemistry,...
Acetyl-CoA carboxylase (ACCase) catalyses the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation. In Arabidopsis thaliana, ACC1 and ACC2, two genes locate...
The reductase activity was susceptible to inhibition by several sulfhydryl reagents; it was lost when the synthase was dissociated into one-half molecular weight subunits or when the incubation mixture was depleted of CoA. It was competitively inhibited by acetyl-CoA, butyryl-CoA, methylmalonyl-CoA,...
signaling in macrophages by oleate activated the oxidation of α-keto acids via branched-chain keto-acid dehydrogenase, which accelerates the degradation of branched-chain amino acids to replenish tricarboxylic acid cycle intermediates via acetyl-CoA and/or succinyl-CoA, and promoted citrate synthesis21...
In the mitochondria, FAO is characterized by a series of breakdown reactions catalyzed by four major enzymes encoded by ACADM, ECHS1, HADH/HADHA/HADHB, and ACAA2, which results in the generation of acetyl-CoA, NADH, and FADH2. Recent studies have shown that blocking of FAO inhibits tumor ...
Fatty acid biosynthesisis the preferred pathway to accumulate energy storage compounds in many organisms. During biosynthesis, fatty acids are activated asthioesterswithcoenzyme A(i.e. fatty acyl-CoAs) oracyl carrier protein(i.e. fatty acyl-ACPs) [36]. Therefore, fatty acyl-CoAs or fatty acyl...