在人类转移性癌中发现FAK的表达水平增加和/或FAK激活。Zhao等人报道,CUL5-SOCS3复合物的缺乏诱导了整合素β1的沉积,随后激活了FAK/SRC信号,增强了小细胞肺癌(SCLC)的转移。另一项研究显示,DGKA与SRC/FAK复合物相互作用并活化,促进上皮-...
关键词:黏着斑激酶;src;心肌肥大;信号转导 心肌肥大指心肌细胞增大而无细胞分裂.从分子水平上,心肌肥大分3个环节:胞 外肥大刺激信号,胞内信号转导及核内基因转录活化.最终诱发细胞发生肥大表型变 化.诱发心肌肥大的刺激因素主要包括:机械应激,多种神经体液因子,如儿茶酚胺 ...
Transforming Growth Factor β Induces Clustering of HER2 and Integrins by Activating Src-Focal Adhesion Kinase and Receptor Association to the Cytoskeleton It has been proposed that cross talk between integrin and growth factor receptor signaling such as ErbB2 (HER2) is required for activation of down...
LncRNA KCNQ1OT1 regulates proliferation and cisplatin resistance in tongue cancer via miR-211-5p mediated Ezrin/Fak/Src signaling Shanyi Zhang, Hanyu Ma, Daming Zhang, Shule Xie, Weiwei Wang, Qunxing Li, Zhaoyu Lin & Youyuan Wang Cell Death & Disease volume 9, Article number: ...
To study the mechanism whereby Tac-β1 inhibits cell spreading, we examined the effect of Tac-β1 on early signaling events following integrin engagement namely FAK and Src signaling. We infected primary fibroblasts with adenoviruses expressing Tac or Tac-β1 and found that Tac-β1 prevented FAK...
Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol 2006; 18: 516–523. Article CAS Google Scholar O'Connor KL, Chen M, Towers LN . Integrin alpha6beta4 cooperates with LPA signaling to stimulate Rac through AKAP-Lbc-mediated RhoA activation. Am J Physiol...
7、igh affinity binding site recognized by the SH2 domain of Src family kinases and leads to the recruitment and activation of Src through the formation of a bipartite kinase complex. Activation of the FAK-Src complex is central to regulation of down-stream signaling pathways that control cell ...
Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase that acts as a substrate for Src and is a key element of integrin signaling. FAK plays an important role in cell spreading, differentiation, migration, cell death, and acceleration of the G1 to S phase transition...
Cancer stem cells (CSCs) are responsible for aggressive tumor growth, metastasis and therapy resistance. In this study, we evaluated the effects of Shikonin (Shk) on breast cancer and found its anti-CSC potential. Shk treatment decreased the expression o
D. Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr. Opin. Cell Biol. 18, 516–523 (2006). Article CAS Google Scholar Schaller, M. D. Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions. J. Cell Sci. 123, 1007–1013 (2010). ...