Egbosimba EE: Evolutionary history of d-lactate dehydrogenases: A phylogenomic perspective on functional diversity in the FAD binding oxidoreductase/transferase type 4 family - ME () Citation Context ...equence has identified two Ldh genes, LdhA andLdhB, that are approximately 26 cM apart [16,17...
The structure of Erv2p, determined by X-ray crystallography to 1.5 Å resolution, reveals a helix-rich dimer with no global resemblance to other known FAD-binding proteins or thiol oxidoreductases. Two pairs of cysteine residues are required for Erv2p activity. The first (Cys-Gly-Glu-Cys) ...
Dihydrolipoamide dehydrogenase (E3) is a member of the pyridine nucleotide-disulfide oxidoreductase family. Thr residues are highly conserved. They are at the active site disulfide-bond regions of most E3s and other oxidoreductases. The crystal structure of Azotobacter vinelandii E3 suggests that the ...
The V/IXGX1–2GXXGXXXG/A motif can be used to search genomic sequence data and to annotate the function of proteins containing the motif as oxidoreductases, including proteins of previously unknown function. 展开 关键词: sequence motif Rossmann fold hydrogen bond FAD-binding NAD(P)-binding ...
A subset of the proteins that adoptthe Rossmann fold also bind to nucleotide cofactors such as FAD andNAD(P) and function as oxidoreductases. These Rossmann folds canoften be identified by the short amino acid sequence motif, GX1–2GXXG.Here, we present evidence that in addition to this ...
thatismorestronglyindicative thanpreviouslydescribedmotifsofRossmannfoldsthatbindFADor NAD(P).TheV/IXGX 1–2 GXXGXXXG/Amotifcanbeusedtosearch genomicsequencedataandtoannotatethefunctionofproteinscontain- ingthemotifasoxidoreductases,includingproteinsofpreviously unknownfunction. q2002PublishedbyElsevierScienceLtd...
Cristescu ME, Egbosimba EE: Evolutionary history of d-lactate dehydrogenases: A phylogenomic perspective on functional diversity in the FAD binding oxidoreductase/transferase type 4 family. J Mol Evol 2009, 69 : 276-287. PubMed Abstract Publisher Full Text Return to textCristescu, M.E.,...
Antley-Bixler syndrome (ABS), a steroidogenesic disorder, was attributed to deleterious mutations of the POR gene, encoding NADPH:cytochrome P450 oxidoreductase (CYPOR), the obligatory electron donor for microsomal cytochrome P450-(CYP) catalyzed reactions. CYPOR contains both FAD and FMN cofactors....
The structure of Erv2p, determined by X-ray crystallography to 1.5 脜 resolution, reveals a helix-rich dimer with no global resemblance to other known FAD-binding proteins or thiol oxidoreductases. Two pairs of cysteine residues are required for Erv2p activity. The first (Cys-Gly-Glu-Cys) ...
(2004) FAD assembly and thylakoid membrane binding of ferredoxin:NADP+ oxidoreductase in chloroplast. FEBS Letters 564, 116-120.Onda Y,,Hase T.FAD assembly and thylakoid membrane binding of ferredoxin:NADP+ oxidoreduetase in chldoroplasts. FEBS Letters . 2004...