Antley-Bixler syndrome (ABS), a steroidogenesic disorder, was attributed to deleterious mutations of the POR gene, encoding NADPH:cytochrome P450 oxidoreductase (CYPOR), the obligatory electron donor for microsomal cytochrome P450-(CYP) catalyzed reactions. CYPOR contains both FAD and FMN cofactors....
NDOR1 NADPH dependent diflavin oxidoreductase 1 [Homo sapiens (human)] This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domain... entrezgene 被引量: 0发表: 0年 Identification and characterization of ...
化学名:NDOR1, ID (NDOR1, NR1, NADPH-dependent diflavin oxidoreductase 1, NADPH-dependent FMN and FAD-containing oxidoreductase, Novel reductase 1) (FITC) CAS番号. 英語名:NDOR1, ID (NDOR1, NR1, NADPH-dependent diflavin oxidoreductase 1, NADPH-dependent FMN and FAD-containing oxidoreductase,...
Various flavin analogs were used as alternate substrates or competitive inhibitors to characterize the FMN binding sites of the NADH- and NADPH-specific FMN oxidoreductases from Beneckea harveyi. Several polyhydroxyl compounds were found... B Nefsky,Marlene DeLuca - 《Archives of Biochemistry & Bioph...
The specific reactivity of the adenylate portion of FAD has been delineated by the following observations on the behavior of adenosyl-replaced analogues of FAD and of AMP with D-amino acid oxidase ( D-amino acid:O 2 oxidoreductase (deaminating), EC 1.4.3.3): 1. 1. Substitution of deoxy...
Riboflavin, FMN, and FAD were analyzed with HPLC (see above). qRT-PCR and Transcriptome Analysis Total RNA was isolated according to the TRIzol Reagent protocol (Ambion) or with the RNeasy Plus Mini Kit (QIAGEN). The quality of the RNA was determined with the Agilent 2100 BioAnalyzer (RNA...
The overall folding of both HPAHs is very similar but there are significant deviations at the cofactor and substrate-binding site. For instance, the adenine moiety of FAD binds at a loop that is not present in the Acinetobacter enzyme, which is in accordance with the FMN- dependent nature ...
The overal kinetic study of the inhibition by superoxide dismutase (superoxide: superoxide oxidoreductase, ED 1.15.1.1) of the oxygen-mediated reduction of cytochrome c in the xanthine oxidase reaction showed that the catalytic reaction ... Y Sawada,I Yamazaki - BBA - Enzymology 被引量: 376发表...
Flavin analysis indicated that WT had a protein:FAD:FMN ratio of approximately 1:1:1, whereas approximately 1:0.1:0.9 was observed for V492E, which retained 9% of the WT k(cat)/K(m) in NADPH:cytochrome c reductase assays. V492E was reconstituted upon addition of FAD, post-purification...
1. The effects of N 1-alkylnicotinamide chloride micelle formation on selected properties of FAD, FMN and NADH were studied. 2. Critical micelle concentrations were determined spectrophotometrically for N 1-decyl-, N 1-undecyl- and N 1-dodecylnicotinamide chlorides. Ionic strength effects were obs...