One of these is FOXRED1, a 486-amino acid FAD-dependent oxidoreductase. FOXRED1 is a member of the D-amino acid oxidase (DAO) family. A structural model of FOXRED1 reveals a large substrate-binding cavity and a putative oxygen-binding site. These features strongly suggest FOXRED1 is ...
The FAD-dependent oxidoreductase from Chaetomium thermophilum ( Ct FDO) is a novel thermostable glycoprotein from the glucose–methanol–choline (GMC) oxidoreductase superfamily. However, Ct FDO shows no activity toward the typical substrates of the family and high-throughput screening with around 1000 ...
DepH efficiently converts an immediate FK228 precursor to FK228 in the presence of NADP. We conclude that DepH is an FAD-dependent pyridine nucleotide-disulfide oxidoreductase, specifically and efficiently catalyzing a disulfide bond formation in FK228. 展开 关键词: PROTEINS ...
quinone oxidoreductase (NDH-2) family and is divided into three domains: the 6-OH-FAD-binding domain (residues 10–111 and 246–327), the NAD(P)H-binding domain (residues 112–245), and the C-terminal membrane-anchoring domain (CTD, residues 328–373) (Supplementary Fig.S1a–c). The...
However, glucose oxidoreductases capable of DET are limited. One of the most prominent GDHs capable of DET is a bacteria-derived FADGDH complex (bFADGDH). bFADGDH has three distinct subunits; the FAD harboring the catalytic subunit, the small subunit, and the electron-transfer subunit, which ...
化学名:NDOR1, ID (NDOR1, NR1, NADPH-dependent diflavin oxidoreductase 1, NADPH-dependent FMN and FAD-containing oxidoreductase, Novel reductase 1) (FITC) CAS番号. 英語名:NDOR1, ID (NDOR1, NR1, NADPH-dependent diflavin oxidoreductase 1, NADPH-dependent FMN and FAD-containing oxidoreductase,...
Fassone E, Duncan AJ, Taanman JW, Pagnamenta AT, Sadowski MI, Holand T, Qasim W, Rutland P, Calvo SE, Mootha VK, Bitner-Glindzicz M, Rahman S (2010) FOXRED1, encoding an FAD-dependent oxidoreductase complex-I-specific molecular chaperone, is mutated in infantile-onset mitochondrial ...
An FAD-dependent pyridine nucleotide-disulfide oxidoreductase is involved in disulfide bond formation in FK228 anticancer depsipeptide. Chem Biol. 2009; 16 (6):585–593. doi: 10.1016/j.chembiol.2009.05.005. [ Cross Ref ]Wang C, Wesener SR, Zhang H, Cheng YQ. 2009. An FAD-dependent ...
Both LPO and the cellular susceptibility to ferroptosis are regulated by the independent activities of glutathione peroxidase 4 (GPX4), that neutralizes lipid peroxides, and ferroptosis suppressor protein 1 (FSP1), an oxidoreductase that reduces coenzyme Q10 (Bersuker et al., 2019; Doll et al.,...
The associated reductase component HadX has similarity to other NADH:flavin oxidoreductases like TcpX, TftC, and HpaC, but is so far not characterized in detail [100]. 2.1.4. Biotechnological Relevance of Group D Flavoprotein Monooxygenases Hydroxylated aromatic compounds are of interest for ...