靶点 factor Xa 作用机制 factor Xa抑制剂(激活型凝血因子X抑制剂) 治疗领域 神经系统疾病心血管疾病呼吸系统疾病+ [1] 在研适应症 血栓形成缺血性卒中全身性栓塞+ [7] 非在研适应症 急性冠状动脉综合征急性缺血性卒中急性淋巴细胞白血病+ [20] 原研机构 Bristol Myers Squibb Co. 在研机构 Bristol-Myers Squib...
In order to adapt the anti-factor Xa assay for the microfluidic chip, a florescence probe was selected, which greatly enhance the robustness of the measurement using small sample volume. The real-time monitoring of anti-factor Xa level was demonstrated in rats receiving LMWH for 7 hours. The ...
activity (performed without heparin) andheparin cofactoractivity. The assay using heparin cofactor activity is able to detect all clinically relevant cases of ATIII deficiency. Factor Xa is probably a better target enzyme than thrombin because factor Xa is not affected by the presence of the other...
A 1-stage APTT-based Factor assay is used for the measurement of Factors VIII, IX, XI and XII. It can also be used for assaying Factors X, V and II [Prothrombin] although a PT-based assay is more commonly used. Factor XII can also be assayed using this technique as can Pre-Kallikre...
Furthermore, although the assay is suitable to quantify the coagulation property of cell therapeutic products, it might fail to reflect their behaviors in vivo, as many environmental milieus, such as inflammation, hypoxia, or Ca2+ in serum, might immensely change their TF-mediated coagulant ...
FV/PT 3.9.1.2.2 Failure of any control to give a result with the correct genotype invalidates the assay and requires that the assay be repeated. FV/PT 3.9.1.3 Interpretation of results. Sample genotype is determined by examining the melting curve for the presence or 450 absence of peaks ...
Specifically, we conducted whole genome sequencing (WGS), single-nuclei RNA sequencing (snRNA-seq), and single-nuclei assay for transposase-accessible chromatin sequencing (snATAC-seq) on cells from the healthy retinae of 20 human donors. We mapped single-cell eQTLs (sc-eQTLs), single-cell caQ...
(Fig.6d). Electrophoretic mobility shift assay (EMSA) experiments further verified that TcBR-C-z2 directly binds to theTcAK1andTcAK2promoter regions to regulate their expression (Fig.6e). Our interpretation is that the opposite hormonal regulation ofTcAK1andTcAK2was primarily mediated by TcBR-C-...
Improving clinical interpretation of the anti-platelet factor 4/heparin enzyme-linked immunosorbent assay for the diagnosis of heparin-induced thrombocytopenia through the use of receiver operating charac- teristic analysis, stratum-specific likelihood ratios, and bayes theorem. Chest 2013;144(4):1269-...
Recombinant OsNAM12.1 binding to promoter fragments of all six genes was confirmed through the electrophoretic mobility shift assay (EMSA; Figure S10). The EMSA results demonstrated variable extent of binding of the recombinant OsNAM12.1 to the specific competitor, despite similar experimental conditions...