修饰凝血因子VII的催化活性位点以产生有效阻断血凝固级联的化合物. Modified catalytically active sites Factor VII to give compound effectively blocking the blood coagulation cascade. 这一修饰使得凝血因子VIIa实质上不能激活血浆凝血因子X或IX. This modifica
The meaning of FACTOR VII is a clotting factor in normal blood that is formed in the kidney under the influence of vitamin K and may be deficient due to a hereditary disorder or to a vitamin K deficiency —called also autoprothrombin I, cothromboplastin,
LOW PROCONVERTIN (FACTOR VII) AND IMPAIRED BLOOD CLOTTING DUE TO GROWTH HORMONE DEFICIENCY IN THE RATPediatric Research publishes original papers, invited reviews, and commentaries on the etiologies of diseases of children and disorders of development, extending from molecular biology to epidemiology. ...
Autoimmune Clotting Dysfunction Properties of the Factor VIII Protein Thefactor VIII(FVIII) protein includes the domains A1, A2, A3, B, C1, C2, and acidic spacers (Toole et al., 1984; Wood et al., 1984). This domain structure is shared between FV andFVIII. FVIII is produced in several...
Koller, F., Loeliger, A., and Duckert, F. Experiments on a new clotting factor (factor VII). Acta haemat. 1951, 6, 1.Koller, F., Loeliger, A., and Duckert, F.: Experiments on a new Clotting Factor (Factor VII). Acta Haematol., 1951, 6, 1....
With their help, coagulation parameters, such as the status of clotting factors (V, VII, X) or other hemostasis-relevant parameters, such as fibrinogen, prothrombin, antithrombin III, (activated) protein C, and vWF can be analyzed (Perchuc and Wilmer, 2010). To distinguish between factor VII...
Preparation of vitamin K-dependent proteins, such as clotting factors II, VII, IX and X and clotting inhibitor Protein C 热度: A Comparison of Developmental Outcomes of Adolescent Neonatal Intensive Care Unit Survivors Born with a Congenital Heart Defect or Born Preterm ...
We conclude that inhibitors may differ in their reactivity with factor VIII molecules contained in clotting factor concentrates, and that there is factor VIII epitope variation between different concentrates. These findings have implications for the selection of concentrates for the treatment of inhibitor ...
blood clottingfactor VIII,andall four died of AIDS.46 In the 1990s, because China had banned imports of blood and blood products from other countries, hemophiliacs relied on domestically-produced clottingfactor VIII,some of which was infected with HIV ...
Endogenous activated factor VII (FVIIa) plays a crucial role in the effective coagulation process. The clotting drug NovoSeven® (Novo Nordisk A/S, Bagsvaerd, Denmark) is structurally nearly identical to endogenous FVIIa and is produced by recombination from a baby hamster kidney cell line. ...