factor VIII n. A protein substance in blood plasma that is an essential part of the blood-clotting process. Most cases of hemophilia are caused by a genetic defect that leads to a deficiency of this factor. Also calledantihemophilic factor. ...
These factors make the clotting times obtained with the one-stage assay shorter than expected on the basis of the factor VIII content, resulting in a significant overestimation of the factor VIII activity. For the same reason, the one-stage assay is often unsuitable to determine factor VIII in...
Factor VIII is bound to vWF for stability and its half-life decreases significantly in the absence of vWF. The activated form of factor VIII separates from vWF and is thermodynamically unstable. Dissociation of a particular region in its structure called the A domain causes loss of activity. ...
Rossix的高质量试剂,用于凝血研究、诊断和质量控制。Rossix合成了一种凝血因子的显色底物,可用于血液凝血因子的检测。Rossix提供用于因子VIII(FVIII)、因子IX(FIX)和凝血酶原活性测定的显色试剂盒。此外,Rossix还开发了高灵敏度显色分析方法,用于制药行业中因子IX(FIX)和免疫球蛋白产品的质量控制,包括因子IX(FIXa)和...
32, 33, 42 Whole blood from FVIIInull mice expressing high levels of pFVIII, equivalent to ∼0.2 U/mL of murine blood, has been reported to partially correct hemostatic function on thromboelastography, although prolonged clotting time was still shown.13, 20 We confirmed these prior findings ...
摘要: PURPOSE: To obtain with high yield the title factor contg. no infectious action substance and being highly purified without damaging the activity by applying a mild treatment in which heat treatment for viral inactivation and gel filtration are combined to a cryoprecipitate of human plasma.收...
PATIENTS with factor VIII deficiency and prolonged skin bleeding time (von Willebrand's syndrome) who receive fresh blood or plasma from normal donors or from patients with hæmophilia A with very low factor VIII activity show a much higher factor VIII activity in their plasma than could possi...
of Medicine and Paediatrics at The Medical College of Wisconsin. "The clearance of administered factor concentrates is greater in children than we see in adults, which leads to burdensome treatment regimens involving multiple injections per week. By providing high-sustained factor VIII activity levels...
Factor VIII activity was approximately 1 U/ml measured as human Factor VIII in the 1-step clotting test, 2-step clotting test or chromogenic Factor VIII test (Immunochrom® Factor VIII:C, Immuno). A preparation according to the invention which was isolated as described in Example 2 was ...
The yield of factor VIII clotting activity (VIII:C) and factor VIII antigen (VIIIR:Ag) was compared in blood drawn from the treated and untreated donors. To prevent degradation of VIII:C by fibrinolysis, tranexamic acid was added to the plasma from treated donors immediately after separation ...