(redirected fromFactor V Leiden mutation) Thesaurus Medical Legal Acronyms Encyclopedia mu·ta·tion (myo͞o-tā′shən) n. 1.The act or process of being altered or changed. 2.An alteration or change, as in nature, form, or quality. ...
The incidence of deep vein thrombosis (DVT) in individuals with heterozygous Factor V Leiden mutation is low. However, DVT risk may be substantially increased when accompanied by nephrotic syndrome. Anticoagulation remains the mainstay of therapy but intervention may be necessary in clinically severe ...
Heterozygous Factor V Leiden mutation may provide a survival advantage in patients during severe sepsisAn abstract is unavailable. This article is available as a PDF only.doi:10.1097/00003246-200212001-00163YanSau Chi BettyCritical Care Medicine
We report here the evolution of the thrombin generation profile while taking combined oral contraceptives and after their discontinuation in a woman with heterozygous factor V Leiden mutation. The proband exhibited a distinctly prothrombotic thrombin generation profile including markedly decreased thrombomodulin...
A single missense mutation (R506Q) due to a G/A transition (G1691A) in exon 10 of the factor V gene is regarded as the causative molecular defect, resulting in factor V Leiden which is correlated with APCR. Identification of this mutation by polymerase chain reaction-based methods is ...
Stroke in a Child with Heterozygous Factor V Leiden Mutation [Heterozigot Faktör V Leiden Mutasyonu olan İnmeli Bir Çocuk]Although thrombosis is seldom seen in children, reports of young patients with thrombosis are becoming more frequent with time. Activated protein C resistance, caused ...
3. De Stefano Ⅴ, Martinelli I, Leone G, et al. The risk of recurrent deep venous thrombosis among heterozygous carriers of both factorⅤ Leiden and the G20210A prothrombin mutation [J]. N Engl J Med, 1999, 341(11):801-806.
It is well documented that factor V Leiden mutation (FVL) is a common hypercoagulable risk factor in the Caucasian population. Patients with homozygous FVL mutation have an increased risk for venous thromboembolism. However, there have been few cases of heterozygous FVL mutation associated with ...
Frequency of gene mutation was compared with its occurrence in 100 healthy controls.One patient with inflammatory bowel disease without thromboembolic events was heterozygous for factor V Leiden mutation. whereas no patient with a thromboembolic event had factor V Leiden mutation. No patients (either ...
By screening 174 healthy Lebanese subjects, 25 were shown to carry the FV-Leiden mutation, giving an allele frequency of 7.4% and an overall prevalence rate of 14.4%. Of the 25 FV-Leiden carriers, 24 were in the heterozygous state while one was in the homozygous states. No statistical ...