: a point mutation producing an abnormal version of factor V that is resistant to inactivation and causes prolonged clotting of blood 2 also factor V Leiden thrombophilia : a genetic disorder caused by factor V Leiden that is marked by an increased risk of abnormal blood clot formation leadin...
Blood donorsAPCR testPCR-RFLPVenous thrombosis (VT) is a common disease with multifactorial pathogenesis. Factor V Leiden mutation (G1691A) (FVL) is the most common risk factor in venous thrombosis. The prevalence of FVL varies according to geography and ethnicity. Hence, in several countries ...
蛋白别名:Activated protein C cofactor; Coagulation factor V; coagulation factor V (proaccelerin, labile factor); coagulation factor V jinjiang A2 domain; Factor 5; factor V Leiden; Factor5; Proaccelerin, labile factor 基因别名:F5; FVL; PCCF; RPRGL1; THPH2 ...
Factor V Leiden is an autosomal dominant disorder of blood clotting associated with hypercoagulability, thrombophilia, and renal disease. We present the first reported case of xanthine calculi in a patient with Lesch-Nyhan syndrome and Factor V Leiden who was treated with allopurinol. A renal ...
clotting factor,coagulation factor- any of the factors in the blood whose actions are essential for blood coagulation Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc. Want to thank TFD for its existence?Tell a friend about us, add a link to ...
Factor V Leiden results from a mutation in the factor V gene G1691A that causes a missense mutation, changing the arginine to glutamine at the site (Arg506Gln).[5]Factor V Leiden is associated with thromboembolic disease and increased aPC resistance.[7]This mutation slows the aPC modification...
ABO blood group genotypes and the risk of venous thrombosis: effect of factor V Leiden Among the 471 patients, 92 (19.5%) carried factor (F)V Leiden compared with 14 (3.0%) of the 471 controls, yielding an OR for venous thrombosis of 7.9 (95%... VM Morelli,MCHD Visser,HL Vos,......
Some investigators speculate that the mild prothrombotic state conferred by the mutation could have reduced mortality from bleeding associated with childbirth or trauma in premodern times.5,18 In several studies, Factor V Leiden heterozygotes had significantly less blood loss during menses, childbirth, ...
Blood 2002;99:3102–3110. 50. Grody WW, Griffin JH, Taylor AK, Korf BR, Heit JA, ACMG Factor V. Leiden Working Group. American College of Medical Genetics consensus statement on Factor V Leiden mutation testing. Genet Med 2001;3:139 –148. 51. Van Cott EM, Laposata M, Prins MH....
In any discussion of blood clotting factor V, one must remember that in addition to its role in preventinghemorrhage, factor V helps to regulate coagulation reactions, so that mutations that prevent its cleavage by activatedprotein C(factor V Leiden) predispose the patient to thrombotic rather than...