factor V Lei·den -ˈlī-dᵊn 1 : a point mutation producing an abnormal version of factor V that is resistant to inactivation and causes prolonged clotting of blood 2 also factor V Leiden thrombophilia : a genetic disorder caused by factor V Leiden that is marked by an ...
Factor V Leiden (FVL) is the name of a specific gene mutation which leads to a hypercoagulability state with serious clinical consequences [5]. Less than two decades of its discovery, the pathophysiol- ogy, clinical consequences, and therapeutic management of the thrombophilic state associated to...
PATHOGENIC MECHANISMS AND MOLECULAR BASIS Factor V Leiden is a genetic disorder characterized by a poor anticoagulant response to APC. APC is a natural anticoagulant protein that cleaves and inactivates procoagulant Factors Va and VIIIa, thereby downregulating further thrombin generation.5,6 APC in...
Factor V Leiden is an autosomal dominant disorder of blood clotting associated with hypercoagulability, thrombophilia, and renal disease. We present the first reported case of xanthine calculi in a patient with Lesch-Nyhan syndrome and Factor V Leiden who was treated with allopurinol. A renal ...
The inherited resistance to activated protein C (APC resistance) is a frequent risk factor for thrombosis and is the most common hereditary blood clotting disorder so far identified. While the commercially available activated thromboplas... M Arlt,LJ Behnken,B Heicke,... - 《Laboratoriumsmedizin...
The risk of thrombosis before age 40 is approximately 1 in 10,000 persons per year, rising to 1 in 100 persons per year after age 75.4 Factor V Leiden is a missense mutation in the clotting factor V gene.5 The mutation is commonly referred to as R506Q. This results in a protein ...
CNS disorderPurpose: Factor V Leiden and factor II 20210A are inherited disorders of the clotting system that occur frequently in patients with deep vein thrombosis. We conducted this study to determine whether these factors are also common in patients with pulmonary embolism. Subjects and Methods:...
16 (i.e. a peptide derived by seminal protein vescicle number IV, SV-IV) to assess its capacity to inhibit the procoagulant activity of normal clotting factor V or Factor V Leiden (FVL). We found that SV-IV protein has potent anti-inflammatory and immunomodulatory properties and also ...
摘要: Spontaneous coronary artery dissection is a rare but increasingly recognized cause of acute myocardial ischemia in young adults, especially in women. We report a case of spontaneous coronary dissection in a young healthy man who was also a carrier of the factor V Leiden gene mutation....