personal or family history of a genetic clotting disorder, such asfactor V Leiden thrombophilia being 40 or older smoking cigarettes having a body mass index (BMI) in theobeserange using estrogen-based contraception, such asbirth control pills takinghormone replacement medication (HRT) having had a...
Blood coagulation factorsare proteins, most of which were discovered when a genetically inherited bleeding disorder was discovered in patients. A newly discovered coagulation factor was often named after the patient in whom it was first recognized, but nowadays the Roman numerals I through to XIII...
FACTOR V LeidenND-YAG lasersSEXUAL intercourseDIABETIC retinopathyCOUGHValsalva retinopathy is a rare disease in which the pressure in the eye increases, leading to the development of a pre-retinal hemorrhage. It frequently occurs in completely healthy patients and leads to sudden a...
There are two different mechanisms whereby blood clotting may be initiated (Figure 1). The principal mechanism, known as the tissue factor (TF) pathway or the extrinsic coagulation cascade, involves the expression of TF (thromboplastin or factor III) on the cells of the intima of the damaged ...
Increased TG invariably indicates thrombotic risk, whether it is due to deficiency of antithrombin or an excess of prothrombin. Also in disorders in the protein C pathway (deficiency of proteins S and C, factor VLeiden) thrombin generation is higher than normal. This holds for plasma clotting as...
In clotting methods, coagulation is triggered through the intrinsic pathway by using APTT reagents or through the extrinsic pathway with the use of tissue factor. In both cases calcium ions are added to a final concentration of usually 5-10 mmol/L. Commercial kits and reagents are available for...
In factor IX, two cleavages take place also releasing an activation peptide of a molecular weight approximately equal to 11 kDa from the internal region of the precursor molecule. Blood coagulation has to be well controlled to avoid any risk of bleeding or of clotting. Thus, deregulation of ...
factors Va and VIIIa. There are two different mechanisms whereby blood clotting may be initiated (Figure 1). The principal mechanism, known as the tissue factor (TF) pathway or the extrinsic coagulation cascade, involves the expression of TF (thromboplastin or factor III) on the cells of the...