In addition to antigen-specific BCR signaling, signals mediated through innate receptors such as TLRs are crucial for the fine-tuning of B cell activation and function. Signals mediated through TLRs, in particular TLR7 and 9, have been shown to control the break of tolerance in B cell-mediated...
The proteolytic activity of Pep4p is required to contrast apoptotic cell death while the non-proteolytic part of this protein is involved in its anti-necrotic function [13]. In addition Pep4p, as well as CatD, shows a protective role in acetate-induced apoptosis in both yeast and colorectal ...
Intricate regulatory mechanisms control each step in the mRNA’s life cycle and allow for the integration of intrinsic and external signals. In the following, we will focus on selected examples that illustrate how post-transcriptional gene expression can be controlled by signaling cascades. 2.1. ...