Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that are capable of killing virally infected and/or cancerous cells. Nearly 20 years ago, NK cell-mediated immunotherapy emerged as a safe and effective treatment approach for patients with advanced-stage leukaemia. Su...
In the present study, we aimed to explore NK cell dynamics and the impact of the CD47/SIRPα axis in patients with colon cancer. We observed a dramatic, time-dependent decrease in NK cell numbers post-surgery, while IFNγ levels, which are indicative of NK cell activity, remained unchanged...
Osteoarthritis (OA) is a degenerative joint disease marked by the breakdown of cartilage, where apoptosis plays a key role. Although apoptosis-related genes in OA have been studied, a detailed analysis of PANoptosis-related genes and the search for thera
The rhizosphere, also known as the epicentre of microbe-microbe and plant–microbe interactions, has been categorized into three sub-zones: the endorhizosphere, encompassing the root cortex and endodermis where microorganisms and mineral ions reside between plant cells; the rhizoplane, the middle zone ...
In this review, we discussed the different treatment modalities, including small molecule targeted drugs, peptide drugs, antibody drugs, cell therapy, and gene therapy. It will provide a detailed explanation of each method, addressing their status of development, clinical challenges, and potential ...
Sepsis is a life-threatening condition caused by an excessive inflammatory response to an infection, associated with high mortality. However, the regulatory mechanism of sepsis remains unclear. In this study, bioinformatics analysis revealed the novel ke
Compounds that attack the integrity of the cell envelope could be pivotal here, given the distinctive properties of bacterial cell surfaces which are often not directly protein-encoded, making them less susceptible to mutation-induced alterations3,8. For example, it has been suggested that Lipid II...
the intended cell type that do not cause immune reactions or toxicity. Even if the NP attaches to the intended cell with excellent selectivity and specificity, the internalization efficiency can also be swayed by the ligand density, shape, size, and surface charge of the NP [23]. In reality...
In addition, the challenges and clinical translation prospects of developing CAR-M as a new cell therapy are discussed. Graphical abstract This review summarizes recent advances in the CAR-Macrophage technology platform for the treatment of non-tumor diseases, highlighting the critical role of chimeric...
NK cell infiltration in endometrial tissue. The proportion of mononuclear macrophages in the ENR group was slightly higher than that in the ER group(6.75%) at 8.86%. And the proportion of endothelial cells was not significantly different from that in the ER group. Interestingly, the proportion ...