Generally, the two main considerations relating to NK cell therapies are the choice of NK cell source and the method of in vivo enhancement of NK cell function; determining approaches to optimize both of these aspects is of high clinical interest. Therapeutic NK cells include haploidentical NK cel...
Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that are capable of killing virally infected and/or cancerous cells. Nearly 20 years ago, NK cell-mediated immunotherapy emerged as a safe and effective treatment approach for patients with advanced-stage leukaemia. Su...
Exploring NK‐Cell molecules that impact the immune response and microenvironment in head and neck squamous cell carcinomadoi:10.1111/jcmm.18045Shao, PengHu, Wei‐WeiShi, Xin‐lianShu, Ming‐yangLi, Dong‐YaZhou, TingtingZhao, Qi‐TaoJournal of Cellular & Molecular Medicine...
Immune cells present within the TME play a crucial role in recognizing and eliminating cancer cells during the early stages of tumor development [20]. However, their function eventually becomes restricted through various mechanisms. In a recent study, an intriguing tumor T-cell metabolic circuit has...
The two most prevalent subtypes of epithelial ovarian carcinoma (EOC) are ovarian clear cell carcinoma (OCCC) and high-grade serous ovarian carcinoma (HGSC). Patients with OCCC have a poor prognosis than those with HGSC due to chemoresistance, implying t
In this review, we discussed the different treatment modalities, including small molecule targeted drugs, peptide drugs, antibody drugs, cell therapy, and gene therapy. It will provide a detailed explanation of each method, addressing their status of development, clinical challenges, and potential ...
the proportion of core ARGs and suppressing stochastic ARGs in the phyllosphere and litter, while it had little effect on the ARGs in the soil. Additionally, microbial generalist abundance increased, but specialist abundance decreased in the phyllosphere and litter, with no effect in the soil, ...
For peptides derived from small variants, also score the wild type counterpart in order filter out those where the wild type also scores high, to avoid self-immunity, T cell recognition probability Score the peptide hydrophobicity of amino acids at T cell receptor (using sources like *IEDB)) ...
Multiple studies have indicated thatT. gondiimodulates the cytokine response by either inhibiting or augmenting it, resulting in an antagonized immune response. Recently, Charles et al. reported that CD4+T-cell activation is suppressed by the cell surface protein programmed death ligand 1 (PD-L1) ...
In this review, we discussed the different treatment modalities, including small molecule targeted drugs, peptide drugs, antibody drugs, cell therapy, and gene therapy. It will provide a detailed explanation of each method, addressing their status of development, clinical challenges, and potential ...