Recent developments into cell regenerative therapy, such as stem cells, exosomes, and platelet-rich plasma (PRP), seek to treat hair loss with fewer side effects and increased longevity. AGA is thought to be caused by disruption of communication between the various types of stem cell niches in...
Recently, exosomes secreted by menstrual mesenchymal stem cells have been identified as inhibitory agents of tumor angiogenesis and modulators of the tumor cell secretome in prostate and breast cancer. However, their direct effect on endothelial cells and paracrine mediators have not yet been ...
Mesenchymal stem cells (MSCs) have the capacity for both self-renewal and cell type differentiation6. An increasing number of studies have shown that the therapeutic function of MSCs is mainly attributed to the paracrine effect mediated by MSC secretory factors, with studies reporting that exosomes ...
来自美国化学协会的学者检索并分析了CAS数据库中EVs在治疗和诊断领域中应用研究的发表情况,统计结果显示干细胞来源EVs(stem cells derived EV, SC-EVs)的相关研究位列第2,其中间充质干细胞来源的EVs(mesenchymal stem cells derived EVs, MSC-EVs)研究热度最高,发表文章数量高达4000篇。 图2. 不同细胞来源外泌体...
accepted that the therapeutic potential of stem cells may be mediated largely by the paracrine factors, so harnessing the paracrine effects of stem and progenitor cells without affecting these living, replicating, and potentially pluripotent cell populations is an advantage in terms of safety and ...
study mesenchymal stem cells (mscs) with regenerative and differentiation capabilities have received much attention among ophthalmologists and scientists as an alternative modality in thetreatment of corneal diseases. recently, a research...
MSCs, a kind of stem cell with multipotent capabilities, may be located in many organs such as bone marrow and adipose. MSCs have the ability to differentiate into several cell types, including osteoblasts, adipocytes, chondroblasts and myocytes. MSCs-derived exosomes participate in intercellular com...
Accumulating evidence has clarified that stem cells release nano-vesicles, known as exosomes, which may serve as mediators of cell-to-cell communication and may potentially transmit stem cell phenotypes to recipient cells, facilitating stem cell maintenance, differentiation, self-renewal, and repair. ...
During the recent years, there was an increasing interest in stem cell therapy in ASD, and specifically, mesenchymal stem cells (MSC). Moreover, it has been suggested that the therapeutic effect of the MSC is mediated mainly via the secretion of small extracellular vesicle that contains ...
Mesenchymal stem cells (MSCs), one of the non-endothelial cell types present in the perivascular environment, have been shown to secret exosomes to modulate intercellular communications between MSCs and their target cells. In this study, we initially isolated exosomes secreted by human adipose-derived...