Our results reveal a remarkable evolutionary variation of this essential RNA degradation machine in eukaryotes. The yeast and human RNA exosome is structurally related to prokaryotic phosphorylases but degrades RNA only via associated hydrolytic activities. Here the authors show that the RNA exosome of...
真核生物核酸外切体_exosome_的研究进展_杨敏
The processing and degradation of RNA sequences is ubiquitous, and these activities can be separated into different classes on the basis of their mechanism and function. The clearest functional differences exist between RNA maturation that will generate a usable RNA from its precursor and RNA degradat...
The exosome complex of 3′–5′ exonucleases participates in RNA maturation and quality control and can rapidly degrade RNA-protein complexes in vivo. However, the purified exosome showed weak in vitro activity, indicating that rapid RNA degradation requires activating cofactors. This work identifies ...
16 days ago Leave a comment Strontium-enhanced exosomes, derived from synovial mesenchymal stem cells, offer a novel therapeutic approach for temporomandibular joint osteoarthritis, improving extracellular vesicle efficacy and miRNA loading to combat cartilage degradation... Read More » Page...
Messenger RNA (mRNA) has emerged as a promising therapeutic molecule with numerous clinical applications in treating central nervous system disorders, tumors, COVID-19, and other diseases. mRNA therapies must be encapsulated into safe, stable, and effective delivery vehicles to preserve the cargo from...
rst1 and ripr mutants accumulate RNA quality control siRNAs (rqc-siRNAs) produced by the post-transcriptional gene silencing (PTGS) machinery when mRNA degradation is compromised. The small RNA populations observed in rst1 and ripr mutants are also detected in mutants lacking the RRP45B/CER7 ...
Lipid bilayer protects from enzymatic degradation Snapshot of living process Transcriptome & Proteome Information Actionable Biomarkers including RNA, protein, and DNA Ideal for clinical trials Patient Stratification insights with liquid biopsy Wide indication range including oncology, neurology, metabolic, card...
所有的RNA 都是从一条长的前体加工处理而来,形成成熟的RNA 发挥功能,之后进行降解.RNA 的降解需要5忆-3忆 核酸外 切酶、3忆-5忆 核酸外切酶及核酸内切酶的参与.在真核细胞中,部分3忆-5忆 核酸外切酶所进行的RNA 降解依赖于一种称为核 酸外切体(exosome)的复合物.该复合物由9 个核心蛋白亚基组成,已有的证...
The eukaryotic \\{RNA\\} exosomedoi:10.1016/j.sbi.2014.01.011AbstractThe eukaryotic RNA exosome is an essential multi-subunit ribonuclease complex that contributes to the degradation or processing of nearly every class of RNA in both the nucleus and cytoplasm. Its nine-subunit core shares ...