More skin appendages were observed in exosomes loaded hydrogel treated wound, indicating the potential to achieve complete skin regeneration. This study provides a new access for complete cutaneous wound regeneration via a genipin crosslinked dual-sensitive hydrogel loading hUCMSCs derived exosomes....
The therapeutic benefits of many cell types involve paracrine mechanisms. Inspired by the paracrine functions of exosomes and the sustained degradation properties of microcapsules, here we report the therapeutic benefits of exosome-loaded degradable poly
The EXO loaded in the alginate‐based hydrogel was used as a bioactive scaffold to preserve the EXO in the wound site in the animal model. The physical and biochemical properties of EXO loaded Alg hydrogel were characterized and results proved that fabricated structure was biodegradable and ...
Exosome-loaded hydrogels as wound dressing The use of wound dressings is a common clinical practice to protect damaged tissue against the environment and bacterial infection. An ideal dressing also facilitates wound closure and actively supports the healing process by providing an optimal wound environmen...
Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation Abstract Foreign body response (FBR) to biomaterials compromises the function of implants and leads to medical complications. Here, we report a hybrid alginate microcapsule...
Therefore, the promising exosome-loaded hydrogels can be designed for craniofacial bone regeneration. This review lists the packaging techniques for exosomes and hydrogel and discusses the development of a biocompatible hydrogel system and its potential for exosome continuous delivery for craniofacial bone ...
isolated from hUC-MSCs. The gelatin sponge loaded with exosomes did not lead to significant cell toxicity, skin irritation, or hemolysis, and there was good compatibility in SD rats. Additionally, the effectiveness of the gelatin sponge loaded with exosomes in hemostasis and wound healing was ...
M2 microglia-derived exosome-loaded electroconductive hydrogel for enhancing neurological recovery after spinal cord injury Pengfei Guan, Lei Fan, Zhaobo Zhu, Qinfeng Yang, Xinchang Kang, Junji Li, Zuyu Zhang, Shencai Liu, Can Liu, Xuelian Wang, Jing Xu, Kun Wang & Yongjian ...
To address the multiple needs of chronic diabetic wound healing, a self-healing, tissue adhesive, antioxidant, provascular hydrogel loaded with 4-Arm-PEG-Thiol, Ag+, exosomes, CNTs, and metformin hydrochloride was designed herein. The synthesis diagram of the hydrogel is presented inFig. 1B. ...
The study focused on preparing a targeted PD-L1 exosome loaded with siRNA to evaluate its efficacy against lung cancer. The researchers optimized the preparation process and determined the binding ratio of the targeted nanovesicle/siRNA complex by assessing physical parameters such as particle size, ...