Abstract The therapeutic benefits of many cell types involve paracrine mechanisms. Inspired by the paracrine functions of exosomes and the sustained degradation properties of microcapsules, here we report the therapeutic benefits of exosome-loaded degradable poly(lactic-co-glycolic acid) microcapsules with ...
The exosome-encapsulating microcapsules, which can be lyophilised, may offer alternative treatment options for vitreoretinal diseases.#Degradable polymeric porous microcapsules loaded with exosomes from mesenchymal stem cells or regulatory T cells led to the restoration of retinal thickness in mice with ...
Hydrogels are carrier platforms for controlled and sustained release of loaded Exos after introduction into the injured sites [29,30]. Using an amalgamated system, hydrogels are the potential to support simultaneously the cell-to-cell interaction and release the loaded materials [111]. Hydrogels with...
The development of natural membranes as coatings for nanoparticles to traverse the blood-brain barrier (BBB) presents an effective approach for treating central nervous system (CNS) disorders. In this study, we have designed a nanogel loaded with PACAP a
Chitosan (CS) and chitosan-based hydrogels are nontoxic, biocompatible and degradable, properties that are all helpful in the field of biomedicine, particularly bone tissue engineering. Its porous structure also promotes cell attachment and proliferation. A hybrid CS-based hydrogel loaded with bioactive...