More skin appendages were observed in exosomes loaded hydrogel treated wound, indicating the potential to achieve complete skin regeneration. This study provides a new access for complete cutaneous wound regeneration via a genipin crosslinked dual-sensitive hydrogel loading hUCMSCs derived exosomes....
This article investigates the characteristics of exosomes, their molecular mechanism in wound healing, and the advantages of the hydrogel delivery system. Also, published reports on the potential of exosome-loaded hydrogels in skin regeneration have been reviewed. Graphical abstract Download: Download ...
The EXO loaded in the alginate‐based hydrogel was used as a bioactive scaffold to preserve the EXO in the wound site in the animal model. The physical and biochemical properties of EXO loaded Alg hydrogel were characterized and results proved that fabricated structure was biodegradable and ...
Additionally, the hydrogel system is a family of multipurpose platforms made of cross-linked polymers with considerable water content, outstanding biocompatibility, and tunable physiochemical properties for the efficient delivery of commodities. Therefore, the promising exosome-loaded hydrogels can be ...
Exosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property Facilitates/promotes growth plate injury repair. Bioact Mater. 2022;10:145–58. PubMed CAS Google Scholar Feng F, Song XY, Tan Z, Tu YJ, Xiao LY, Xie PF, Ma YH, Sun XM, Ma JW, Rong LM, He LM. ...
To address the multiple needs of chronic diabetic wound healing, a self-healing, tissue adhesive, antioxidant, provascular hydrogel loaded with 4-Arm-PEG-Thiol, Ag+, exosomes, CNTs, and metformin hydrochloride was designed herein. The synthesis diagram of the hydrogel is presented inFig. 1B. ...
loaded hydrogel patches [129]. In a similar work, Zhang et al. used dendritic cell Exos loaded alginate hydrogel (30 µg exosomal protein/15 µl alginate hydrogel) for the regulation of immune cell response in an MI mouse model [132]. In an experiment, DEXs were labeled with DIR and...
Luo L, Gong J, Wang Z, Liu Y, Cao J, Qin J, Zuo R, Zhang H, Wang S, Zhao P, et al. Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration. Bioact Mater. 2022;15:29–...
Furthermore, in a mouse calvarial defect model, the combination of hMSC-derived exosomes with injectable chitosan hydrogel led to bone regeneration by downregulating noggin through the inhibition of miR-29a [134]. Hyaluronic acid is a linear nonsulfated glycosaminoglycan composed of alternating ...
Besides, the water absorption capacity decreased, making the hydrogel resemble a solid material. In addition, the hydrolysis rate becomes slower, so the composite hydrogel has a certain load-bearing capacity and can be used as a bone tissue engineering material in vivo for a prolonged time. ...