Programmed cell death protein-1/programmed cell death ligand-1 (PD-1/PD-L1) pathway blockade is a promising new cancer therapy. Although PD-1/PD-L1 treatment has yielded clinical benefits in several types of cancer, further studies are required to clarify predictive biomarkers for drug efficacy ...
治疗前水平:可能与外泌体PD-L1在免疫失调的作用有关。外泌体PD-L1水平越高,T细胞难以通过抗PD-1治疗再活化。 治疗中:外泌体PD-L1增加与T细胞再活化有关,可以反映抗PD-1疗法引发的成功的抗肿瘤免疫。虽然外泌体PDL1响应于IFN-γ的升高可以使肿瘤细胞适应性地灭活CD8 T细胞,但这是徒劳的,因为PD-L1 / PD-1...
PDL1 can be expressed on the surface of tumour cells, immune cells and other cells in the tumour microenvironment but is also found in extracellular forms. Recent studies have explored the importance of different forms of extracellular PDL1, such as on exosomes or as a freely soluble protein,...
(G) Schematic of in vitro functional assay of exosomal PDL1. (H) Quantification of IL-2 released by Jurkat cells following Raji presentation of super-antigen. Jurkat (PD1), Jurkat T cells overexpressing PD1; Raji (Parental), Raji B cells expressing low levels of PD-L1; Raji (PD-L1), ...
J. Freeman, "The impor- tance of exosomal PDL1 in tumour immune evasion," Nature Reviews. Immunology, vol. 20, no. 4, pp. 209–215, 2020. [19] Y. Tang, P. Zhang, Y. Wang et al., "The Biogenesis, biology, and clinical significance of exosomal PD-L1 in c...
Abstract 3146: EGFL6 induces immunosuppressive functions of tumor-associated myeloid cells and mediates resistance to anti-PDL1 therapy Myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) are critical negative regulators of immunity in cancer. Understanding fact... S Sinno,...
Programmed cell death protein 1 NSCLC: Non-small cell lung cancer IFN-γ : Interferon-γ TNF-α : Tumor necrosis factor α MiRNA: MicroRNA Tregs: Regulatory T cells PDL1: Programmed cell death ligand 1 LUAD: Lung adenocarcinoma RCC: Renal cell carcinoma TAMs: Tumor-associated ...
MRTF-A-NF-κB/p65 axis-mediated PDL1 transcription and expression contributes to immune evasion of non-small-cell lung cancer via TGF-β Exp. Mol. Med. (2021) Google Scholar [102] S. Muto, et al. Tumor β-catenin expression is associated with immune evasion in non-small cell lung cance...
Tumour cells evade immune surveillance by upregulating the surface expression of programmed death-ligand 1 (PD-L1), which interacts with programmed death-1 (PD-1) receptor on T cells to elicit the immune checkpoint response1,2. Anti-PD-1 antibo
The importance of exosomal PDL1 in tumour immune evasion Article21 January 2020 Introduction Tumor cells can evoke systemic immune perturbations for rapid expansion. Recent studies have discovered that beyond upregulating the expression of programmed death-ligand 1 (PD-L1) on cellular surface1,2, tumo...