Right of the heatmap includes a summary of the evolution experiments in daughter subclones of clone CQ. c, Correlation between true arm-level event frequencies in the HMEC in vitro evolution screen (n = 90 in vitro evolution experiments; gain minus loss frequencies) and breast cancer arm...
In summary, we previously elucidated how an adaptive gustatory trait can rapidly emerge under human-imposed ‘natural’ selection25,28 and in this study, we demonstrated that the emergent trait creates mismatches in sexual communication. Overall, pre-oral and oral processing of oligosaccharides by coc...
In summary, both the TN and PD TME were characterized by the relative predominance of macrophage over T cell infiltration; however, the phenotypic characteristics of these infiltrating immune cells differ between the two groups. At PD, there was infiltration by an IDO1+ macrophage population, of ...
In summary, it is apparent that southern Madagacar and the Nampula Block share similar features. Both areas manifest widespread Cambrian to Ordovician (∼518–440 Ma) low-pressure, high-temperature metamorphism that postdates the Kuungan collisional type metamorphism. Late-tectonic N–S extension ...
Table 1 Summary of genome assembly and annotation Full size table Fig. 1 Cocos nuciferagenome assembly, and genomic features.aThe circos diagram ofCn. tallandCn. dwarf. The circles from outer to inner separately represented GC (guanine-cytosine) content (I); gene density (II); transposable ele...
Summary The Horizon platform modernizes virtual workspace delivery and management with an agile, lightweight, approach that spans the hybrid cloud. The result is secure, fast, and simple virtual desktop and application delivery that extends the best digital workspace experience to all apps. This rele...
classified as discordant. As breast cancer subtype is known to be the main determinant of tumor biology (notably tumor grade and proliferation), immune infiltration, response to anti-cancer agents and, ultimately, oncologic outcomes, we displayed the results of the clinical section of the paper acc...
The oldest conodonts are represented by the paraphyletic grade of paraconodonts, which appeared in the Cambrian Period and were characterized by poorly mineralized phosphatic tissues rich in organic matter. Paraconodonts were succeeded by the more derived group, euconodonts, which dominated the lineag...
Summary Tumor evolution from a single cell into a malignant, heterogeneous tissue remains poorly understood. Here, we profile single-cell transcriptomes of genetically engineered mouse lung tumors at seven stages, from pre-neoplastic hyperplasia to adenocarcinoma. The diversity of transcriptional states inc...
In summary, we have pioneered a cost-efficient, scalable preparation strategy for large-area flexible CNFs films with uniformly distributed diatomic FeN3-CoN3 sites. In order to maintain the flexibility of CNFs after the introduction of metallic components, we employed a novel metal-organic precurs...