leukaemia (HeH ALL) is driven by nonrandom chromosomal gains, which have been suggested to arise early - even before birth. Here, the authors use single-cell whole genome sequencing and in silico modelling to show that HeH ALL aneuploidies could originate early and follow punctuated evolut...
The complex interspersed pattern of segmental duplications in humans is responsible for rearrangements associated with neurodevelopmental disease, including the emergence of novel genes important in human brain evolution. We investigate the evolution of LCR16a, a putative driver of this phenomenon that encod...
Unlike grade II and III astrocytomas, pilocytic astrocytomas (PAs) are circumscribed astrocytic gliomas, they do not progress to higher-grade tumors, and most commonly arise in the optic pathway, brainstem, and cerebellum177. In comparison to higher-grade diffuse gliomas, PAs have less complex ge...
Evolution of sex determination in plants: insights from grapevine The dominant theoretical model for the evolution of dioecy and sex chromosomes in plants relies on two sex-determining genes, carrying, one, a dominant female-sterility mutation and, the other, a recessive male-sterility mutation [47...
(coding for p53 protein) is often mutated in human cancers, in the majority in the DNA binding domain. Cancers with a high incidence ofTP53mutations are high-grade serous ovarian cancer, lung, colon, brain or pancreatic cancer [33]. TheTP53gene mutations of missense, nonsense, frameshift or...
et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N. Engl. J. Med. 366, 883–892 (2012). CAS PubMed PubMed Central Google Scholar Burrell, R. A. et al. Replication stress links structural and numerical cancer chromosomal instability. Nature 494, 492...
Propionic anhydride was mixed with LC–MS-grade water in a ratio of 1:100, and 3 μl of the anhydride mixture was added immediately to the histone samples, vortexed and incubated for 2 min at room temperature. The reaction was quenched with 3 μl of 80 mM hydroxylamine, ...
The Human Gene Mutation Database (HGMD) and its exploitation in the fields of personalized genomics and molecular evolution. Curr. Protoc. Bioinformatics. 2012;Chapter 1:Unit1.13. Lappalainen I, Lopez J, Skipper L, Hefferon T, Spalding JD, Garner J, et al. dbVar and DGVa: public archives ...
Teaching evolution: Narratives with a view from three southern biology teachers in the USA This case study explored sociocultural forces that influenced three 10th grade public high school biology teachers' instructional goals, instructional acts... M. Jenice Dee Goldston,P Kyzer - 《Journal of Rese...
25. Evolution 26. Evolution theory 27. Heterotroph hypothesis 28. Ecology 29. Ecological Organization 30. Ecosystems 31. Biosphere and humans 更多 新内容 版本记录 版本5.3.3 New Exam Questions and Flashcards App 隐私 查看详情 开发者“Feraco media Inc.”已表明该 App 的隐私规范可能包括了下述...