Cell-free DNA (cfDNA) quantitation in patients' plasma has been recently applied in monitoring several cancer types. This study evaluates the diagnostic potential of cfDNA in PDAC patients.Sikora, KatarzynaBedin, ChiaraVicentini, CaterinaMalpeli, GiorgioD'Angelo, EdoardoSperandio, NicolaLawlor, Rita T...
Cell-free DNA (cfDNA) quantitation in patients’ plasma has been recently applied in monitoring several cancer types. This study evaluates the diagnostic potential of cfDNA in PDAC patients.MethodsPlasma cfDNA levels and integrity ratio were assayed using quantitative real-time PCR of Alu-repeat ...
Plasma cell-free DNA next-generation sequencing to diagnose and monitor infections in allogeneic hematopoietic stem cell transplant patients. Open Forum Infect Dis. 2018;5(12):ofy301. doi:10.1093/ofid/ofy301PubMedGoogle Scholar 9. Ivy MI, Thoendel MJ, Jeraldo PR, et al. ...
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Therefore, changes in cell free DNA (cfDNA) could play a crucial role in acute flares of SLE [5]. The existence of cell free DNA in human blood plasma was first described in 1948 by Mandel und Métais [6]. Subsequent research has been mainly focused on the detection and quantification ...
Table 2 Clinical application of CTCs in PC in recent years Full size table Circulating tumour DNA Cell-free DNA (cfDNA) is a crucial genetic component found in the bloodstream; its origin primarily stems from apoptotic, necrotic, and actively secreted fragments originating from healthy, inflamed, ...
High levels of cell free DNA (cfDNA) in human blood plasma have been described in patients with autoimmune diseases. The aim of this study was to determine the levels of cfDNA in systemic lupus erythematosus (SLE) patients and to assess fluctuations of cfDNA concentrations compared to the course...
It was found to be toxic and induced massive loss of cell viability through DNA damage and programmed cell death of all doses compared to control. Our results demonstrate that carbon nanotubes indeed can be very toxic at sufficiently high concentrations from environmental and occupational exposure ...
Article Open access 30 July 2024 Highly parallel and efficient single cell mRNA sequencing with paired picoliter chambers Article Open access 30 April 2020 Limitations and opportunities of technologies for the analysis of cell-free DNA in cancer diagnostics Article 31 January 2022 Introduction...
The cellular effects of CDK2/1 siRNA knockdown and purine-based CDK2/1 inhibitors, NU2058 and NU6102, were measured in anti-estrogen-sensitive and resistant breast cancer cell lines. Results: CDK2 knockdown caused G1 accumulation, whereas CDK1 depletion caused G2/M slowing, and dual CDK1/...