Dear Editor, ETV6–RUNX1 (previously TEL–AML1) is the most common fusion gene associated with childhood ALL, which occurs in approximately 25% of pediatric ALL patients receiving diagnoses between the ages of 2–10 years and is associated with favorable prognoses [1, 2]....
The ETV6–RUNX1 (alias TEL–AML1) fusion gene also originates prenatally [4]; however, the latency period to leukemia development is usually broader in these cases, with a typical peak between 2 and 5 years [5]. The presence of the ETV6–RUNX1 fusion gene in cord blood cells of ...
FormatRNA DescriptionN/A Technical Data Left GeneETV6 Right GeneRUNX1 1st of two Breakpoints ETV6(E5)-RUNX1(E4) Fusion Left Breakpoint chr12:12022903:+ Right Breakpoint chr21:36259393:- Cosmic ID COSF2247 2nd of two Breakpoints ...
ETV6(E5)-RUNX1(E4) Fusion Left Breakpoint chr12:12022903:+ Right Breakpoint chr21:36259393:- Cosmic ID COSF2247 2nd of two Breakpoints ETV6(E5)-RUNX1(E3) Fusion Left Breakpoint chr12:12022903:+ Right Breakpoint chr21:36265260:-
ObjectiveTo investigate the clinical significance of monitoring ETV6-RUNX1 fusion gene in children with acute lymphoblastic leukemia (ALL) after allogeneic stem cell transplantation (allo-HSCT) . MethodsClinical data of 13 children received allo-HSCT in Peking University Institute of Hematology from May...
【关键词】造血干细胞移植;白血病,淋巴细胞,急性;融合基因,ETV6一RUNXl;微小残留病基金项目:国家自然科学基金青年项目(81300440);首都卫生发展科研专项项目(2016—1—4082);国家自然科学基金(81670175)Clinical significance of monitoring ETV6-RUNXl fusion gene expression in children with acutelymphoblastic leukemia ...
The ETV6-RUNX1 translocation results in the production of a fusion protein that probably acts in a dominant negative fashion to interfere with normal function of the transcription factor RUNX1. 【翻译】ETV6-RUNX1易位...
基金 国家自然科学基金青年基金(22007086)。 关键词 微量残留病 急性B淋巴细胞白血病 ETV6/RUNX1融合基因 流式细胞术 预后 Minimal residual disease Acute B-lymphoblastic leukemia ETV6/RUNX1 fusion gene Flow cytometry Prognosis 分类号 R446.1 [医药卫生—诊断学] 登录...
Objective To investigate the clinical significance of monitoring ETV6-RUNX1 fusion gene in children with acute lymphoblastic leukemia (ALL) after allogenei... 洪艳,秦亚溱,徐永艳,... - 《中华血液学杂志》 被引量: 0发表: 2017年 儿童与成人急性B淋巴细胞白血病临床及分子遗传学比较 定量RT-PCR等技术检...
Clinical features, early treatment responses, and outcomes of pediatric acute lymphoblastic leukemia in China with or without specific fusion transcripts: a single institutional study of 1,004 patients[J]. Am J Hematol, 2012,87(11):1022-1027. DOI: 10.1002/ajh.23307 . 返回引文位置Google Scholar...