The gene described herein (designated ESX) is located at chromosome 1q32 a region amplified in 50% of early breast cancers. The ESX gene of this invention is associated with the etiology of various cancers including breast cancers. Detection of the ESX gene or gene product is thus of ...
Frequent Overexpression of ETS-Related Gene-1 (ERG1) in Prostate Cancer Transcriptome A correction to the article "Frequent overexpression of ETS-related gene-1 (ERG1) in prostate cancer transcriptome" that was previously published in "Oncogene" is presented. G Petrovics,A Liu,S Shaheduzzaman,...
To test the prognostic significance of ETS-related gene (ERG) expression in cytogenetically normal primary acute myeloid leukemia (AML). Pretreatment blood samples from 84 cytogenetically normal AML patients aged less than 60 years, who were characterized for BAALC expression, FLT3 internal tandem dup...
Another type of human cancer, Ewing's sarcoma, is characterized by translocations of a number of different Ets factors, erg, ETV1, E1-AF, FEV, or fli-1, to the EWS gene (23, 24, 25, 26, 27). Under normal physiological conditions, Ets factors play a critical role in the regulation...
genetica, proteine, expresion genica, nucleotidos, proteinas, genetique, desarrollo embrionario, genetics, dna, proteins, genomas, genomes, genes, gene, nucleotide, embryonic development, chromosome, chromosomes, adn, genome, expression des genes, drosophila, nucleotides, cromosomas, developpement ...
Recurrent gene fusions in prostate cancer. The discovery of recurrent gene fusions in a majority of prostate cancers has important clinical and biological implications in the study of common epithel... Chandan,Kumar-Sinha,Scott,... - 《Nature Reviews Cancer》 被引量: 1150发表: 2008年 NK cells...
The TEL/ETV6 gene is located at 12p13 and is frequently involved in chromosomal translocations in human malignancies usually resulting in the expression of fusion proteins between the amino terminal part of TEL, and either unrelated transcription factors or protein tyrosine kinases. We report here a...
A gene on 6p21 that encodes a protein belonging to the ETS family of evolutionarily conserved transcriptional regulators, which play key roles in cellular development and differentiation as well as in oncogenesis. ETV7 is predominantly expressed in haematopoietic tissues. Segen's Medical Dictionary. ...
We have isolated an ecdysone-inducible gene, E74, from the early puff at position 74EF in the Drosophila polytene chromosomes. We show that E74 consists of three nested transcription units that derive from unique promoters but share a single polyadenylation site. The 60 kb E74A unit is directly...
2000 . Characterization of a novel ETS gene, TELB, encoding a protein structurally and functionally related to TEL . Oncogene 19 : 4802 – 4806 .Poirel, H., Lopez, R. G., Lacronique, V., Della Valle, V., Mauchauffe, M., Berger, R., Ghysdael, J. and Bernard, O. A. (2000)...