gene regulationMHCtumor immunityvaccineEts family (ETS) transcription factors, characterized by an evolutionally conserved Ets domain, play important roles in cell development, cell differentiation, cell proliferation, apoptosis and tissue remodeling. Most of them are downstream nuclear targets of Ras-MAP...
8. TU J, LI X, WANG J. Characterization of bidirectional gene pairs in The Cancer Genome Atlas (TCGA) dataset[J]. Peer J, 2019,7:e7107. 9. YUAN M, HUANG L L, CHEN J H, et al. The emerging treatment land...
(2004) J Cell Biochem 91, 896-903. Tetsu, O. and McCormick, F. (2017) Clin Transl Med 6, 16. Pathways Explore pathways related to this product. Database Links UniProt ID: P15036 Entrez-Gene Id: 2114 View in PhosphoSitePlus® 限制使用 除非CST 的合法授书代表以书面形式书行明确...
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positive influence of both FN and CIV, particularly effective in stimulating expression of the integrin gene promoters in actively growing cells (such as at 4.5×103 and 2.5×103 cells/cm2 for FN and CIV, respectively), is rapidly lost (particularly for CIV) as cell density increases (Fig. ...
Peripheral T cells are maintained in the absence of vigorous stimuli, and respond to antigenic stimulation by initiating cell cycle progression and functional differentiation. Here we show that depletion of the Ets family transcription factor GA-binding protein (GABP) in T cells impairs T-cell homeo...
factors [J]. Gene,2004,324(1):1-14. 04 Sm th JL,Schaffner AE,Hofme ster JK,et ai. Ets-2 s a target for an akt(prote n k nase B)/ Jun N-term nai k nase s gnai ng pathway n macrophages of motheaten v abie mutant m ce [J]. Mol Cell Biol, ...
as the same DNA sequence can function differently depending on the cell type and/or external stimuli9. Most non-coding variants are thought to affect gene regulation13, but difficulties identifying causal genes, which may lie millions of bases away, and causal cell types, which may only express...
Amajor challenge in the development of a gene therapy for hemophilia A is the selection of cell type- or tissue-specific promoters to ensure factor VIII (FVIII) expression without eliciting an immune response. As liver sinusoidal endothelial cells are the major FVIII source, understanding the ...
Cell, 100: 229-240. Holzbeierlein J, Lal P, LaTulippe E, Smith A, Satagopan J, Zhang L, Ryan C, Smith S, Scher H, Scardino P, Reuter V, Gerald WL (2004) Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen- responsive genes and mechanisms...