Megakaryocyte population in human bone marrow increases with estrogen treatment: a role in bone remodeling? Bone. 2000;27:397–401.Bord, S. , Vedi, S. , Beavan, S.R. , Horner, A. & Compston, J.E. ( 2000 ) Megakaryocyte population in human bone marrow increases with estrogen ...
et al. Estrogen receptor-alpha signaling in osteoblast progenitors stimulates cortical bone accrual. J. Clin. Invest. 123, 394–404 (2013). Article CAS PubMed Google Scholar Borjesson, A. E. et al. The role of estrogen receptor-α and its activation function-1 for growth plate closure in...
Megakaryocyte population in human bone marrow increases with estrogen treatment: a role in bone remodeling? 来自 Semantic Scholar 喜欢 0 阅读量: 42 作者:S Bord,S Vedi,SR Beavan,A Horner,JE Compston 摘要: Skeletal effects of conventional hormone replacement therapy (HRT) are predominately anti...
The role and mechanism of estrogen receptor in bone growth, metabolism and mechano-responsiveness Mechanical signaling plays a critical role in bone growth, remodeling and healing. Recent studies discover that estrogen can modulate proliferation, apoptosis and functional activity of bone cell tissues via...
Estrogen is critical for skeletal homeostasis and regulates bone remodeling, in part, by modulating the expression of receptor activator of NF-κB ligand (RANKL), an essential cytokine for bone resorption by osteoclasts. RANKL can be produced by a variety of hematopoietic (e.g. T and B-cell)...
primordial for healthy bone formation. Although, significant progress has been made to better understand the function of bone stromal cells during bone development and remodeling, their role in breast cancer bone metastasis still remains unclear. The finer appreciation of how bone stromal cells ...
It has long been appreciated that the estrogen receptor (ER) plays an important role in the biology of breast cancer. It is an accepted factor predicting f
Role of Estrogen Receptor Signaling Required for Endometriosis-Like Lesion Establishment in a Mouse Model Endometriosis results from ectopic invasion of endometrial tissue within the peritoneal cavity. Aberrant levels of the estrogen receptor (ER), ERα and ER... KA Burns,KF Rodriguez,SC Hewitt,.....
GPER is present throughout the cardiovascular system, implying a critical role in maintaining cardiovascular physiological function. GPER activation by G1 restored glucose homeostasis and reduced body weight in multiple preclinical male and female models associated with obesity, diabetes, and metabolic abnor...
Estrogen prevents osteoporotic bone loss by attenuating bone resorption; however, the molecular basis for this is unknown. Here, we report a critical role for the osteoclastic estrogen receptor α (ERα) in mediating estrogen-dependent bone maintenance in female mice. We selectively ablated ERα ...