Previous in vitro studies suggest that the membrane G protein-coupled receptor GPR30 also might be a functional ER. Our in vivo analyses of GPR30-inactivated mice revealed no function of GPR30 for estrogen-mediated effects on bone mass but it is required for normal regulation of the growth ...
342 The role of estrogen in bone has also been affirmed. Postmenopausal estrogen deficiency can lead to osteoporosis, which is due to estrogen inducing osteoclast apoptosis through ERs and protecting bone through the inflammatory mediators RANKL and Scl.343,344,345,346 Prospects It has been known ...
Interestingly, the role of mERα signaling for the estrogen response was highly tissue-dependent, with trabecular bone in the axial skeleton being strongly dependent (>80% reduction in estrogen response in NOER mice), cortical and trabecular bone in long bones, as well as uterus and thymus ...
The role of estrogens for male bone health. estrogen receptor (ER)伪 and activation of the androgen receptor result in a stimulatory effect on both the cortical and trabecular bone mass in males. ... C Ohlsson - 《European Journal of Endocrinology》 被引量: 84发表: 2009年 The Effect of ...
Background: Exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos) are considered as candidates for osteoporosis (OP) therapy. Estrogen is critical in the maintenance of bone homeostasis. However, the role of estrogen and/or its receptor in BMSC-Exos treatment of OP, as well as ...
This review summarizes the regulatory effects of bone and bone-derived factors on energy metabolism and discusses future research directions.骨骼约占人体总重量的15%, 主要由骨基质、间充质干细胞系和造血干细胞系组成[1]. 骨基质由有机物和无机物两部分组成, 其中有机物主要包括成骨细胞分泌的I型胶原和...
The Role of Metabolism in Bone Health Bone metabolism is the process by which bones are maintained andremodeled. Several factors influence bone metabolism, including: Hormones Hormones such as estrogen, testosterone, and parathyroid hormone (PTH)play significant roles...
Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. CONTEXT: Despite decades of use and considerable research, the role of estrogen alone in preventing chronic diseases in postmenopausal women remains uncert... GL ...
diseases.186,187,188Furthermore, Lu and coworkers discovered that threeOPRM1SNPs (rs9479769, rs4870268, and rs1998221) were nominally associated with hip, spine, and whole-body BMD phenotypes in female American Caucasians, potentially via effects on alcohol consumption and/or estrogen signaling....
Genistein, a phyto-estrogen, can potentially replace endogenous estrogens in postmenopausal women, but the underlying molecular mechanisms remain incompletely understood. To obtain insight into the effect of genistein on bone differentiation, RNA sequencing (RNA-seq) analysis was used to detect differential...