bone resorptionIL-1IL-6prostaglandin EEstrogen deficiency causes a marked bone loss by stimulating osteoclastic bone resorption. Recent studies on the role of estrogen in bone resorption have focused on the involvement of at least two cytokines, IL-1 and IL-6. It is well known that IL-1 ...
et al. Suppressive function of androgen receptor in bone resorption. Proc. Natl Acad. Sci. USA 100, 9416–9421 (2003). Article CAS PubMed PubMed Central Google Scholar Yeh, S. et al. Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the st...
In ORX mice, seminal vesicle weight and femoral bone mineral density also decreased. Both estrogen and raloxifene normalized the stimulated B-lymphopoiesis and bone resorption induced by ORX. These results show that estrogen also regulates B-lymphopoiesis and bone resorption in male mice. We have ...
E reduces bone resorption, in part, by decreasing differentiation of BMMNCs into mature osteoclasts. This action cannot be explained by decreased concentrations of surface receptors for proresorptive factors. The roles of increases in c-Fms concentration and the proportion of TNFR2((+)) cells are...
However, IL‐6 alone present in bone marrow supernatants from OVX mice again did not stimulate bone resorption. The concurrent addition of IL‐1 (50 pg/ml), IL‐6 (0.2 ng/ml), sIL‐6 receptor (1 ng/ml), and PGE 2 (7 ng/ml), which equaled the endogenous concentrations in bone ...
Estrogen induces TGFP production in bone, and ovariectomy has the opposite effect; TGFP inhibits bone resorption in ovariectomized animals, and TGFP appears... D Hughes,B Boyce - 《Endocrinologist》 被引量: 0发表: 1998年 The role and mechanism of estrogen receptor in bone growth, metabolism ...
Estrogen is critical for skeletal homeostasis and regulates bone remodeling, in part, by modulating the expression of receptor activator of NF-κB ligand (RANKL), an essential cytokine for bone resorption by osteoclasts. RANKL can be produced by a variet
Prostaglandins (PG's) stimulated resorption of fetal rat bone in 48–96 hr tissue culture. The effects of several PG's were compared to the stimulation of bone resorption caused by parathyroid hormone (PTH). PGE1 and PGE2 caused increase... KLEIN DAVID C.,RAISZ LAWRENCE G. - 《Endocrinology...
2. Bone Health Estrogen also plays a crucial role in maintaining bonehealthby slowing bone resorption (the breakdown of old bone tissue) and promoting new bone formation. This can helpprevent bone conditions like osteoporosis, a condition characterized by weak and brittle bones that are more prone...
Bone metastasis is a prominent cause of morbidity and mortality in cancer. High rates of bone colonization in breast cancer, especially in the subtype expressing estrogen receptors (ERs), suggest tissue-specific proclivities for metastatic tumor formatio