Estrogen receptor (ER) signaling is a critical regulator of cell proliferation, differentiation, and survival in breast cancer (BC) and other hormone-sensitive cancers. In this review, we explore the mechanism of ER-dependent downstream signaling in BC and the role of estrogens as growth factors...
Ijichi, N., et al., Estrogen-related receptor gamma modulates cell proliferation and estrogen signaling in breast cancer. J Steroid Biochem Mol Biol, 2011. 123(1-2): p. 1-7.Ijichi N, Shigekawa T, Ikeda K, Horie-Inoue K, Fujimura T, Tsuda H, Osaki A, Saeki T, ...
2a). On the other hand, SMURF1 depletion also activated several signaling including PPAR signaling and TGF beta signaling (Fig. 2b). Since ER alpha signaling is pre-dominant in ER alpha positive breast cancer cells, we further analyzed ER alpha target genes expression change by SMURF1 ...
Crosstalk Between IGF1R and Estrogen Receptor Signaling in Breast Cancer After the discovery that depriving certain breast tumors of estrogen promoted tumor regression, therapeutic strategies aimed at depriving tumors of this ho... DH Fagan,D Yee - 《J Mammary Gland Biol Neoplasia》 被引量: 310...
Hah, N., Kraus, W. L.Hormone-regulated transcriptomes: lessons learned from estrogen signaling pathways in breast cancer cells.Mol Cell Endocrinol.382, 652-664 (2014). Tags Systems BiologyMetabolic RegulationEstrogen Receptor SignalingBreast CancerTranscriptomeSystromeMetabolomeTranscription FactorsMetabolism...
In 293T cells, ERRγ could also stimulate ERE-mediated transcription with or without ERα. These results suggest that ERRγ plays an important role as a modulator of estrogen signaling in breast cancer cells. 展开 关键词: Estrogen-related receptor γ (ERRγ Breast cancer MCF-7 Estrogen ...
Breast cancer ranks no. 1 in women cancer worldwide, while 60–70% are estrogen receptor alpha positive. The estrogen selective modulators, such as tamoxifen, become the effective drugs for controlling ER alpha breast cancer progression. However, tamoxif
AKT alters genome-wide estrogen receptor alpha binding and impacts estrogen signaling in breast cancer Mol Cell Biol, 28 (2008), pp. 7487-7503 Google Scholar 90 S Hua, R Kittler, KP White Genomic antagonism between retinoic acid and estrogen signaling in breast cancer Cell, 137 (2009), pp....
estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in...
Estrogen receptor-positive breast cancer: a multidisciplinary challenge. Wiley Interdiscip Rev Syst Biol Med 2011; 3: 216-230.W. Zwart, V. Theodorou, and J. S. Carroll, "Estrogen receptor- positive breast cancer: a multidisciplinary challenge," Wiley Interdisciplinary Reviews. Systems Biology and ...